Description

n-[S-Methanethiosulfonylcystaminyl]Diethylenetriaminepentaacetic Acid is a specialized bifunctional chelating agent that combines a reactive methanethiosulfonate (MTS) group with the powerful metal-chelating DTPA moiety. This compound is critically important for creating stable, site-specific covalent linkages between chelators and biomolecules, enabling precise radiolabeling and metal complexation. It is primarily needed by researchers and manufacturers in the fields of radiopharmaceutical development, molecular imaging, and targeted drug delivery systems.

Application

• Radiopharmaceutical Precursor: For the site-specific conjugation of radioactive metal isotopes (e.g., 111In, 90Y, 177Lu) to antibodies, peptides, and other targeting vectors for diagnostic imaging and radiotherapy.
• Molecular Imaging Probe Development: Creation of stable, high-affinity contrast agents for SPECT and PET imaging applications.
• Bifunctional Chelator (BFC) in Research: Used in chemical biology and bioinorganic chemistry to introduce metal-binding sites into proteins, nucleic acids, or nanoparticles via disulfide bond formation with free thiol groups.
• Targeted Therapeutic Agents: Conjugation to therapeutic molecules for delivering cytotoxic radionuclides or paramagnetic metal ions to specific disease sites.
• In Vitro Diagnostics: Component in the development of immunoassays and other diagnostic kits requiring stable metal-chelate labels.
• Material Science Functionalization: Modification of surfaces and nanomaterials with metal-chelating properties for catalysis or sensing applications.

Basic Information

Product Name	n-[S-Methanethiosulfonylcystaminyl]Diethylenetriaminepentaacetic Acid
CAS No.	1246817-77-5
Molecular Formula	C22H39N7O14S3
Molecular Weight	737.78 g/mol
Synonyms	DTPA-MTS; S-Methanethiosulfonylcysteamine-DTPA; MTS-DTPA; Bifunctional DTPA-MTS Chelator; (2-{2-[Bis(carboxymethyl)amino]ethyl}[carboxymethyl]amino)acetic acid - S-(2-{[(methylsulfonyl)thio]acetyl}amino)ethyl ester derivative; DTPA linked to Methanethiosulfonate; N-{2-[2-(2-{2-[Bis(carboxymethyl)amino]ethyl}(carboxymethyl)amino)acetamido]ethyl}-2-{[(methylsulfonyl)thio]acetamido}acetamide
EINECS	Contact for details

Quality Control

Our n-[S-Methanethiosulfonylcystaminyl]Diethylenetriaminepentaacetic Acid is produced under strict quality management systems to ensure batch-to-batch consistency and high purity, essential for sensitive research and development applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, NMR and MS for structural confirmation, and functional testing for conjugation efficiency. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant for long-term stability. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake. For short-term use, store desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Functional Activity (Conjugation)	≥ 90% yield

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.