Description

Aliskiren-D6 Hydrochloride is a deuterated internal standard of the renin inhibitor aliskiren, specifically designed for use in quantitative analytical methods. This high-purity reference material is essential for ensuring the accuracy and reliability of pharmacokinetic and metabolic studies in pharmaceutical research and development. It is primarily utilized by analytical laboratories and pharmaceutical companies engaged in bioanalytical method development, clinical trial sample analysis, and drug metabolism and pharmacokinetics (DMPK) research.

Application

• Internal Standard for LC-MS/MS quantification of Aliskiren in biological matrices (plasma, serum, urine).
• Bioanalytical method development and validation for clinical and preclinical studies.
• Drug metabolism and pharmacokinetics (DMPK) research to track drug absorption, distribution, metabolism, and excretion.
• Pharmacokinetic profiling and therapeutic drug monitoring (TDM) studies.
• Quality control and assurance in pharmaceutical manufacturing of Aliskiren-based products.
• Stability-indicating assay development for pharmaceutical formulations.
• Metabolite identification and profiling studies using mass spectrometry.
• Use in regulated environments compliant with Good Laboratory Practice (GLP) and Good Manufacturing Practice (GMP).

Basic Information

Product Name	Aliskiren-D6 Hydrochloride
CAS No.	1246815-96-2
Molecular Formula	C30H47D6ClN3O6
Molecular Weight	Contact for details
Synonyms	Aliskiren-d6 HCl; (2S,4S,5S,7S)-5-Amino-N-(2-carbamoyl-2,2-dimethylethyl)-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methylnonanamide-d6 Hydrochloride; 2(S),4(S),5(S),7(S)-N-(2-Carbamoyl-2-methylpropyl)-5-amino-4-hydroxy-2,7-diisopropyl-8-[4-methoxy-3-(3-methoxypropoxy)phenyl]octanamide-d6 Hydrochloride; SPP100-d6 Hydrochloride; CGP60536B-d6; Tekturna-d6 HCl; Rasilez-d6 HCl
EINECS	Contact for details

Quality Control

Our Aliskiren-D6 Hydrochloride is manufactured under strict quality control protocols to ensure the highest standards of isotopic purity and chemical integrity. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and mass spectrometry, to confirm identity, isotopic enrichment (≥98 atom % D), and chemical purity (typically ≥95%). Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific project or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95%
Isotopic Purity (Atom % D)	≥ 98%
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.