Description

Hydroxyurea CAS NO 1246814-92-5 is a potent antineoplastic and antiviral agent, a synthetic organic compound belonging to the class of urea derivatives. Its primary value lies in its ability to inhibit ribonucleotide reductase, a key enzyme in DNA synthesis, making it a critical therapeutic agent. This product is essential for pharmaceutical manufacturers and research institutions focused on developing treatments for myeloproliferative disorders, sickle cell disease, and antiviral therapies.

Application

• Pharmaceutical Active Ingredient (API): Primary use in the formulation of antineoplastic medications for chronic myelogenous leukemia (CML), polycythemia vera, and essential thrombocythemia.
• Sickle Cell Disease Therapy: Key component in medications that increase fetal hemoglobin production, reducing the frequency of painful crises and acute chest syndrome.
• Antiviral Research: Investigated for its potential activity against HIV and other viral infections as part of combination therapies.
• Oncology Research: Used as a reference standard and biochemical tool in cancer research to study cell cycle arrest and DNA synthesis inhibition.
• Chemical Intermediate: Serves as a building block in the synthesis of more complex pharmaceutical compounds and nucleoside analogs.

Basic Information

Item	Detail
Product Name	Hydroxyurea
CAS No.	1246814-92-5
Molecular Formula	CH4N2O2
Molecular Weight	76.05 g/mol
Synonyms	Hydroxycarbamide; Carbamohydroxamic acid; N-Hydroxyurea; Litalir; Hydrea; Onco-Carbide; HU; SQ-1089; NSC-32065
EINECS	Contact for details

Quality Control

Our Hydroxyurea is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity pharmaceutical standards, including compliance with relevant pharmacopeial monographs (e.g., USP, EP). A detailed Certificate of Analysis (COA), documenting identity, purity, and impurity profiles, is provided with every shipment to guarantee traceability and regulatory compliance for our global B2B clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%
Microbiological Enumeration	Meets Ph. Eur. criteria

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.