Description

4-(tert-Butoxycarbonyloxy)Benzyl Methanethiosulfonate is a specialized, high-purity chemical building block used in advanced organic synthesis and bioconjugation. This compound matters for its role as a key reagent in the site-specific modification of proteins and peptides, enabling the development of novel therapeutics and diagnostic tools. It is primarily needed by research institutions and pharmaceutical companies engaged in bioconjugation, antibody-drug conjugate (ADC) development, and proteomics research.

Application

• Bioconjugation Reagent: For the site-specific labeling and modification of proteins, antibodies, and peptides.
• Antibody-Drug Conjugate (ADC) Linker Chemistry: As a critical component in constructing stable, cleavable linkers for targeted cancer therapies.
• Proteomics and Protein Engineering: Used to introduce functional handles or probes for studying protein structure, function, and interactions.
• Chemical Biology Tool: Enables the study of biological processes through controlled chemical modification of biomolecules.
• Pharmaceutical Intermediate: Serves as a key synthetic intermediate in the production of complex active pharmaceutical ingredients (APIs).
• Material Science: Potential use in creating functionalized surfaces and polymers for biosensor applications.

Basic Information

Product Name	4-(tert-Butoxycarbonyloxy)Benzyl Methanethiosulfonate
CAS No.	1246814-72-1
Molecular Formula	C13H18O5S2
Molecular Weight	318.41 g/mol
Synonyms	Boc-ONB-MTS; (4-(((tert-Butoxycarbonyl)oxy)benzyl) methanethiosulfonate; 4-(Boc-oxy)benzyl methanethiosulfonate; S-(4-((tert-Butoxycarbonyl)oxy)benzyl) methanethiosulfonate; tert-Butyl (4-((methylsulfonylthio)methoxy)phenyl) carbonate; MTS-Boc-ONB; Protein Modification Reagent; Bioconjugation Linker
EINECS	Contact for details

Quality Control

Our 4-(tert-Butoxycarbonyloxy)Benzyl Methanethiosulfonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency suitable for sensitive research and development applications. Certificates of Analysis (COA) with full analytical data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.