Description

1,2-Dioleoyl-Sn-Glycero-3-Phospho-(1'-Myo-Inositol-5'-Phosphate) (Ammonium Salt) is a high-purity, synthetic phospholipid derivative, specifically a phosphatidylinositol 5-phosphate (PI5P) analog, essential for advanced life science research and pharmaceutical development. This compound serves as a critical signaling lipid and a key intermediate in the synthesis of more complex phosphoinositides, enabling the study of intracellular signaling pathways, membrane dynamics, and lipid-protein interactions. It is primarily utilized by researchers and formulators in biochemistry, cell biology, and drug delivery system development, particularly for creating lipid nanoparticles (LNPs) and other advanced vesicular carriers.

Application

• Biochemical Research: As a critical substrate or standard for studying phosphoinositide-specific kinases, phosphatases, and phospholipase enzymes.
• Cell Signaling Studies: Investigation of PI5P's role in cellular processes such as membrane trafficking, cytoskeletal reorganization, and nuclear signaling.
• Lipid Nanoparticle (LNP) Formulation: A functional excipient for designing novel, targeted drug delivery systems, especially for nucleic acid therapeutics (mRNA, siRNA).
• Liposome & Model Membrane Preparation: Used to create asymmetric or specialized liposomal bilayers to mimic specific cellular membrane domains for biophysical studies.
• Pharmaceutical Intermediate: A key building block in the synthetic pathway for more complex, labeled, or modified phosphoinositide derivatives.
• Diagnostic Reagent Development: Potential use in assays and kits designed to detect or quantify specific lipid-protein interactions.

Basic Information

Product Name	1,2-Dioleoyl-Sn-Glycero-3-Phospho-(1'-Myo-Inositol-5'-Phosphate) (Ammonium Salt)
CAS No.	1246303-10-5
Molecular Formula	C47H89NO15P2 • xNH3
Molecular Weight	~970.15 g/mol (Free acid, approximate)
Synonyms	PI(5)P (18:1); DOPI5P; 1,2-Dioleoyl-*sn*-glycero-3-phospho-(1D-*myo*-inositol-5-phosphate); Phosphatidylinositol 5-Phosphate (18:1/18:1); (5'-Phosphonooxy-1'-*myo*-inositol) 1,2-dioleoyl ester; Ammonium salt of PI5P; DOPI(5)P; Synthetic Phosphatidylinositol-5-Phosphate
EINECS	Contact for details

Quality Control

Every batch of our high-purity phospholipids is manufactured and analyzed under strict quality systems. We provide comprehensive Certificates of Analysis (COA) detailing purity, identity, and critical impurities. Our quality assurance protocols are designed to meet the exacting standards of pharmaceutical research and development, ensuring batch-to-batch consistency and reliability for your most sensitive applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below under an inert atmosphere (argon or nitrogen). This product is hygroscopic (moisture-sensitive) and easily oxidized. Allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white waxy solid or film
Identification (MS)	Complies
Identification (NMR)	Complies
Purity (HPLC)	≥ 97.0%
Solvent Content (Residual Solvent)	≤ 2.0%
Water Content (KF)	≤ 1.0%
Fatty Acid Composition (GC)	≥ 95% Oleic acid (C18:1)
Ammonium Content	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.