Description

1,2-Dioleoyl-Sn-Glycero-3-Phospho-(1'-Myo-Inositol-3'-Phosphate) (Ammonium Salt) is a high-purity, synthetic phospholipid derivative, specifically a phosphatidylinositol phosphate (PIP) lipid. This compound is a critical reagent in advanced life science research, particularly for studying lipid-protein interactions, cell signaling pathways, and membrane biophysics. It is essential for researchers and formulators in the pharmaceutical, biotechnology, and diagnostic sectors who require defined, high-quality lipids for liposome preparation, drug delivery systems, and as standards in lipidomics.

Application

• Liposome & Lipid Nanoparticle (LNP) Formulation: A key component for creating targeted drug delivery vehicles, including mRNA-LNP vaccines and cancer therapeutics.
• Cell Signaling & Biochemistry Research: Used as a substrate or ligand to study phosphoinositide-mediated signaling cascades, enzyme kinetics (e.g., kinases, phosphatases), and intracellular trafficking.
• Membrane Biophysics Studies: Incorporated into model membranes (e.g., vesicles, supported lipid bilayers) to investigate membrane curvature, protein recruitment, and lipid domain formation.
• Diagnostic Assay Development: Serves as a coating or capture agent in assays designed to detect specific antibodies or proteins involved in autoimmune or metabolic diseases.
• Pharmaceutical Reference Standard: Employed as a certified reference material (CRM) for quality control and analytical method development in lipid-based drug products.
• Biomimetic Surface Engineering: Used to create functionalized surfaces that mimic cellular membranes for biosensor applications and material-cell interaction studies.

Basic Information

Product Name	1,2-Dioleoyl-Sn-Glycero-3-Phospho-(1'-Myo-Inositol-3'-Phosphate) (Ammonium Salt)
CAS No.	1246303-09-2
Molecular Formula	C47H89NO16P2 • xNH3
Molecular Weight	~970.18 (Free acid, anhydrous basis)
Synonyms	PI(3)P (18:1); DOPI(3)P; 1,2-Dioleoyl-*sn*-glycero-3-phospho-(1D-*myo*-inositol-3-phosphate); Ammonium Salt of Phosphatidylinositol 3-Phosphate; (3'-Phospho)-PtdIns; 1,2-Di-(9Z-octadecenoyl)-*sn*-glycero-3-phospho-(1D-*myo*-inositol-3-phosphate); DOPI3P; PI3P (DO)
EINECS	Contact for details

Quality Control

Our 1,2-Dioleoyl-Sn-Glycero-3-Phospho-(1'-Myo-Inositol-3'-Phosphate) (Ammonium Salt) is manufactured under strict quality management systems. Each batch is characterized using advanced analytical techniques including NMR, HPLC, and MS to confirm identity, purity, and lipid composition. We provide comprehensive Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data, ensuring traceability and compliance with research-grade specifications. Custom synthesis and purification to meet specific project requirements are available.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis. Under these conditions, the product is typically stable for at least 24 months.

Specification

Item	Specification
Appearance	White to off-white waxy solid or film
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Assay (Phosphorus)	≥ 98% (on dried basis)
Solubility	Chloroform, Chloroform/Methanol mixtures
Loss on Drying	≤ 2.0 %
Heavy Metals	≤ 20 ppm
Bacterial Endotoxins	< 10 EU/mg (if applicable)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.