Description

1,2-Dioleoyl-Sn-Glycero-3-[Phospho-Rac-(3-Lysyl(1-Glycerol))] (Chloride Salt) is a high-purity, synthetic phospholipid derivative, specifically a lysyl-phosphatidylglycerol (LPG) analog. This compound is critically important for its role as a key functional lipid in advanced drug delivery systems, particularly for formulating cationic liposomes and lipid nanoparticles (LNPs). It is primarily needed by researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors working on mRNA therapeutics, gene delivery, and novel vaccine development.

Application

• Cationic Lipid Component for Lipid Nanoparticles (LNPs): A critical excipient for formulating stable, efficient LNPs used in mRNA-based vaccines and therapeutics.
• Gene Delivery Vector Development: Used in the research and production of non-viral vectors for plasmid DNA (pDNA) and siRNA delivery.
• Liposome Formulation: Serves as a structural and functional phospholipid in the creation of targeted liposomes for drug encapsulation and delivery.
• Biomembrane & Biophysical Research: Employed in model membrane studies to investigate lipid-protein interactions and membrane dynamics.
• Pharmaceutical R&D: Utilized in pre-clinical and clinical-stage development of novel nanomedicines and advanced therapeutic modalities.

Basic Information

Product Name	1,2-Dioleoyl-Sn-Glycero-3-[Phospho-Rac-(3-Lysyl(1-Glycerol))] (Chloride Salt)
CAS No.	1246303-07-0
Molecular Formula	C48H93N2O10P • Cl
Molecular Weight	Contact for details
Synonyms	18:1 LPG (chloride salt); 1,2-Dioleoyl-sn-glycero-3-phospho-(3'-rac-lysyl(1'-glycerol)) chloride; Lysyl-PG(18:1/18:1); DO LPG; (3R)-3-({[(2R)-2,3-Bis[(9Z)-octadec-9-enoyloxy]propoxy](hydroxy)phosphoryl}oxy)-2-hydroxypropyl (2S)-2,6-diaminohexanoate chloride; L-α-Phosphatidylglycerol, 3'-O-[(2S)-2,6-diamino-1-oxohexyl]-, 1,2-di-(9Z-octadecenoate), chloride salt; Cationic lipid LPG.
EINECS	Contact for details

Quality Control

Our 1,2-Dioleoyl-Sn-Glycero-3-[Phospho-Rac-(3-Lysyl(1-Glycerol))] (Chloride Salt) is manufactured under strict quality systems suitable for pharmaceutical R&D. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure consistency and compliance with exacting research standards. A comprehensive Certificate of Analysis (COA) detailing purity, solvent residues, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C ± 5°C under an inert atmosphere (e.g., argon or nitrogen) due to its hygroscopic and easily oxidized nature. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or waxy solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0% (Area %)
Solvent Residues (GC)	Meets ICH guidelines
Water Content (KF)	≤ 2.0 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.