Description

Desmosterol-D6 is a deuterium-labeled internal standard of desmosterol, a key intermediate in the cholesterol biosynthesis pathway. This high-purity, isotopically labeled compound is essential for ensuring accuracy and precision in quantitative mass spectrometry-based analyses. It is primarily used by researchers and quality control laboratories in the pharmaceutical, biotechnology, and clinical diagnostics sectors for metabolic studies and biomarker quantification.

Application

• Quantitative Bioanalysis: Serves as a critical internal standard for the accurate LC-MS/MS quantification of endogenous desmosterol in biological matrices such as plasma, serum, and tissue homogenates.
• Metabolic Pathway Research: Used in tracer studies to investigate the cholesterol biosynthesis pathway, specifically the activity of the enzyme 24-dehydrocholesterol reductase.
• Biomarker Assay Development: Essential for developing and validating robust clinical diagnostic assays for disorders related to cholesterol metabolism, including desmosterolosis.
• Drug Discovery & Development: Employed in pharmaceutical R&D to study the mechanism of action and efficacy of drugs targeting cholesterol synthesis, such as statins or novel DHCR24 inhibitors.
• Food & Nutritional Science: Applied in research analyzing sterol composition and bioavailability in food products and dietary supplements.
• Reference Material: Used as a certified reference material (CRM) to calibrate analytical instruments and ensure method reliability across laboratories.

Basic Information

Item	Detail
Product Name	Desmosterol-D6
CAS No.	1246298-67-8
Molecular Formula	C27H38D6O
Molecular Weight	390.66 g/mol
Synonyms	(3β)-Cholesta-5,24-dien-3-ol-d6; 24-Dehydrocholesterol-d6; Desmosterol (24,25,25,26,26,26-d6); [26,26,26,27,27,27-2H6]-Desmosterol; 5,24-Cholestadien-3β-ol-d6; (3β)-24-Dehydrocholesterol-d6; Deuterated Desmosterol Internal Standard
EINECS	Contact for details

Quality Control

Every batch of Desmosterol-D6 is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, confirmed by advanced spectroscopic and chromatographic techniques. A comprehensive Certificate of Analysis (COA) detailing purity, isotopic enrichment, and analytical results (NMR, HPLC, MS) is provided with each shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98% (Area %)
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (Titration)	≥ 97%
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.