Description

n-Nervonoyl-1-Deoxysphingosine (M18:1/24:1) is a chemically defined sphingolipid analog, specifically a 1-deoxysphinganine base N-acylated with nervonic acid. This compound is of significant interest in biochemical research for its role in studying cellular signaling pathways, membrane dynamics, and lipid metabolism disorders. It serves as a critical reference standard and synthetic intermediate for researchers in pharmaceutical development, lipidomics, and metabolic disease research, where precise molecular structure is paramount for experimental accuracy and reproducibility.

Application

• Biochemical Research Standard: Used as a high-purity analytical standard for the quantification and identification of sphingolipids in complex biological samples via LC-MS or GC-MS.
• Lipidomics Studies: A key molecule for investigating sphingolipid metabolism, trafficking, and their implications in diseases like diabetes and neuropathy.
• Cell Biology Research: Employed in studies of cell membrane structure, lipid rafts, and ceramide-related apoptotic signaling pathways.
• Pharmaceutical Intermediates: Serves as a building block for the synthesis of more complex sphingolipid analogs and potential therapeutic agents.
• Metabolic Pathway Analysis: Utilized to trace and understand the biosynthesis and catabolism of deoxysphingolipids in model systems.

Basic Information

Product Name	n-Nervonoyl-1-Deoxysphingosine (M18:1/24:1)
CAS No.	1246298-58-7
Molecular Formula	C42H81NO3
Molecular Weight	648.1 g/mol
Synonyms	1-Deoxysphinganine nervonate; (2S,3R)-2-Amino-3-hydroxyoctadecyl (15Z)-tetracos-15-enoate; N-Nervonoyl-deoxysphinganine; M18:1/24:1 Deoxysphingolipid; Deoxysphingosine C24:1; Lipid M(18:1/24:1); Nervonic acid-1-deoxysphingosine amide; 1-Deoxy-D-erythro-sphingosine nervonoyl
EINECS	Contact for details

Quality Control

Our n-Nervonoyl-1-Deoxysphingosine is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to rigorous analytical standards, employing techniques like HPLC, NMR, and mass spectrometry for verification. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term storage, keep the product at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.