Description

n-Palmitoyl-1-Deoxysphingosine (M18:1/16:0) is a synthetic, high-purity sphingolipid analog, specifically a 1-deoxysphinganine ceramide. This compound is of significant interest in biochemical and pharmaceutical research due to its role as a biomarker and modulator in studies of metabolic disorders, including diabetic neuropathy. It is primarily utilized by research institutions and pharmaceutical developers focused on lipid metabolism, cell signaling pathways, and the development of novel therapeutic agents. The product is supplied with a guaranteed Certificate of Analysis to ensure batch-to-batch consistency for critical research applications.

Application

• Biomedical Research: Used as a critical standard and reagent in the study of 1-deoxysphingolipid biology and their association with diseases like hereditary sensory and autonomic neuropathy type 1 (HSAN1) and type 2 diabetes.
• Metabolic Pathway Analysis: Essential for in vitro and in vivo investigations into sphingolipid metabolism, particularly the serine palmitoyltransferase (SPT) pathway and its dysregulation.
• Drug Discovery & Development: Serves as a reference compound and potential target molecule in screening assays for inhibitors of toxic deoxysphingolipid synthesis.
• Diagnostic Tool Development: Employed in the calibration and validation of analytical methods (e.g., LC-MS/MS) for quantifying deoxysphingolipids in biological samples.
• Cell Biology Studies: Applied in research to understand the impact of atypical sphingolipids on cell membrane properties, apoptosis, and insulin resistance.
• Academic & Institutional Research: A key material for universities and research labs conducting fundamental studies in lipidomics and metabolic disorders.

Basic Information

Product Name	n-Palmitoyl-1-Deoxysphingosine (M18:1/16:0)
CAS No.	1246298-56-5
Molecular Formula	C34H67NO3
Molecular Weight	537.90 g/mol
Synonyms	1-Deoxysphinganine C16:0 Ceramide; N-[(2S,3R)-1,3-Dihydroxyoctadec-4-en-2-yl]hexadecanamide; N-Palmitoyl-deoxysphinganine; M18 Ceramide (d18:0/16:0); Deoxysphingolipid C16; 1-Deoxy-sphinganine C16 Ceramide; (2S,3R)-2-Hexadecanamidooctadec-4-ene-1,3-diol; Sa(d18:0/16:0)
EINECS	Contact for details

Quality Control

Our n-Palmitoyl-1-Deoxysphingosine is manufactured under strict quality protocols to ensure the high purity required for sensitive research applications. Each batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment, ensuring full traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, keep under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, ethanol, chloroform

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.