Description

Protac Linker 27 (CAS NO 1246286-33-8) is a specialized bifunctional linker compound designed for the construction of Proteolysis Targeting Chimeras (PROTACs). This molecule is critical for connecting an E3 ubiquitin ligase ligand to a protein of interest (POI) targeting ligand, enabling the targeted degradation of disease-causing proteins. It is an essential research tool for pharmaceutical developers, medicinal chemists, and academic researchers working in the fields of targeted protein degradation, chemical biology, and novel therapeutic discovery.

Application

• PROTAC Molecule Synthesis: Core component for constructing heterobifunctional degraders for cancer, neurodegenerative, and inflammatory disease targets.
• Chemical Biology Research: Used as a tool compound to study ubiquitin-proteasome system (UPS) pathways and validate novel E3 ligase engagements.
• Medicinal Chemistry & Drug Discovery: Enables the exploration of structure-activity relationships (SAR) by varying linker length and composition to optimize degrader potency and selectivity.
• Preclinical Development: Supports the synthesis of candidate PROTAC molecules for in vitro and in vivo pharmacological evaluation.
• Bioconjugation: Serves as a versatile spacer in the conjugation of biomolecules for creating other targeted therapeutic modalities.

Basic Information

Product Name	Protac Linker 27
CAS No.	1246286-33-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	PROTAC Linker 27; Linker for PROTAC 27; (2R,5S)-5-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-1-((S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-methylbutanoyl)pyrrolidine-2-carboxylic acid; Fmoc-Linker 27; Bifunctional PROTAC Spacer 27; Degrader Linker 27; Chemical Probe Linker
EINECS	Contact for details

Quality Control

Our Protac Linker 27 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, essential for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity (typically ≥95% by HPLC), identity confirmation (by NMR and/or MS), and impurity profiles. We support research and development under cGMP-like conditions where required.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This compound is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.