Description

Acetylene-Peg5-Acid CAS NO 1245823-51-1 is a specialized bifunctional PEG derivative featuring an acetylene group for click chemistry and a terminal carboxylic acid for further conjugation. This compound is engineered to serve as a critical heterobifunctional linker in advanced bioconjugation and materials science, enabling the precise and stable attachment of biomolecules, polymers, and surfaces. It is essential for researchers and manufacturers in the pharmaceutical, diagnostic, and nanotechnology sectors who require reliable, high-purity building blocks for developing targeted drug delivery systems, biosensors, and functionalized nanomaterials.

Application

• Bioconjugation Reagent: Used as a heterobifunctional crosslinker for attaching peptides, proteins, or antibodies to nanoparticles, surfaces, or other polymers via click chemistry and amide bond formation.
• Drug Delivery System Development: Facilitates the creation of PEGylated drug conjugates and targeted nanocarriers, enhancing solubility, stability, and circulation time.
• Diagnostic Assay Fabrication: Employed in the surface functionalization of biosensors, microarrays, and diagnostic beads to immobilize capture probes.
• Materials Science & Hydrogel Synthesis: Acts as a key monomer or crosslinking agent for synthesizing smart, functional hydrogels with tailored chemical reactivity.
• Polymer Chemistry: Serves as a macroinitiator or building block for synthesizing complex, multi-functional block copolymers with precise architecture.
• Click Chemistry Scaffold: Provides a reliable acetylene handle for copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions in combinatorial chemistry and library synthesis.

Basic Information

Product Name	Acetylene-Peg5-Acid
CAS No.	1245823-51-1
Molecular Formula	C19H34O9
Molecular Weight	406.47 g/mol
Synonyms	Acetylene-PEG5-acid; Acetylene-PEG5-COOH; 2,5,8,11,14-Pentaoxaheptadec-16-ynoic acid; 17-(2,5,8,11,14-Pentaoxaheptadec-16-yn-1-yl)heptadecanoic acid; Propargyl-PEG5-acid; Alkyne-PEG5-acid; Heterobifunctional PEG Alkyne Acid; PEG-based Alkyne Acid Linker
EINECS	Contact for details

Quality Control

Our Acetylene-Peg5-Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with high-grade material specifications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to guarantee traceability and consistency for your critical research and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation and hydrolysis. This compound is hygroscopic and easily oxidized; allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation. For long-term stability, keep the desiccated container in a freezer.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Acid Value (Titration)	Contact for details
Molecular Weight Confirmation (MS)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.