Description

(1S,2S,3S)-Aprepitant is a high-purity, stereochemically defined active pharmaceutical ingredient (API) and a key intermediate in the synthesis of the antiemetic drug Aprepitant. Its precise stereochemistry is critical for ensuring the efficacy and safety of the final pharmaceutical product, making it an essential component for manufacturers of high-quality generic and branded medications. This compound is primarily targeted at pharmaceutical R&D laboratories and API production facilities focused on developing and scaling up treatments for chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea and vomiting (PONV).

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of the neurokinin-1 (NK1) receptor antagonist, Aprepitant.
• Active Pharmaceutical Ingredient (API) Development: Used in the research and development of generic and proprietary Aprepitant formulations.
• Antiemetic Drug Manufacturing: Essential for producing medications like Emend® and its generic equivalents, used to prevent CINV and PONV.
• Process Chemistry & Scale-Up: Serves as a critical reference standard and starting material for process optimization and commercial-scale API synthesis.
• Analytical Reference Standard: Employed in quality control laboratories for method development, validation, and impurity profiling via HPLC and other chromatographic techniques.
• Clinical Trial Material (CTM) Production: Supplied for the manufacture of drug substances used in clinical studies for new antiemetic therapies.

Basic Information

Product Name	(1S,2S,3S)-Aprepitant
CAS No.	1242175-40-1
Molecular Formula	C23H21F7N4O3
Molecular Weight	534.43 g/mol
Synonyms	(3S)-3-[[(2S,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-ium; (1S,2S,3S)-Aprepitant Isomer; Aprepitant Stereoisomer; Aprepitant Intermediate; L-742,694 (Stereoisomer); NK1 Receptor Antagonist Intermediate
EINECS	Contact for details

Quality Control

Our (1S,2S,3S)-Aprepitant is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and stereochemical integrity, aligning with ICH guidelines. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting results for assay, chiral purity, related substances, residual solvents, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Chiral Purity (Chiral HPLC)	≥ 99.0% (1S,2S,3S)-Isomer
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.