Description

Aprepitant CAS NO 1242175-38-7 is a high-purity active pharmaceutical ingredient (API) belonging to the class of neurokinin-1 (NK1) receptor antagonists. It is a critical component in the formulation of antiemetic medications, specifically designed to prevent chemotherapy-induced nausea and vomiting (CINV). This compound is essential for pharmaceutical manufacturers and research institutions developing and producing advanced therapeutic agents. Its efficacy in blocking substance P in the brain makes it a cornerstone in supportive cancer care protocols.

Application

• Pharmaceutical API: Primary active ingredient in the manufacture of prescription antiemetic drugs.
• Chemotherapy-Induced Nausea and Vomiting (CINV) Prevention: Formulated into capsules and injectables for acute and delayed phase CINV.
• Postoperative Nausea and Vomiting (PONV) Management: Used in clinical settings for prophylaxis against nausea following surgery.
• Research and Development: Reference standard and building block in neuropharmacology and oncology research.
• Drug Product Formulation: Serves as the key component in solid oral dosage forms (e.g., capsules) and intravenous solutions.
• Generic Drug Manufacturing: Critical for companies producing bioequivalent versions of branded aprepitant medications.

Basic Information

Product Name	Aprepitant
CAS No.	1242175-38-7
Molecular Formula	C23H21F7N4O3
Molecular Weight	534.43 g/mol
Synonyms	MK-0869; L-754,030; Emend (Brand Name); 5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1H-1,2,4-triazol-3-one; Neurokinin 1 Receptor Antagonist; Substance P Antagonist; Antiemetic Agent
EINECS	Contact for details

Quality Control

Our Aprepitant is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent pharmaceutical-grade specifications, including identity, purity, and impurity profile. Certificates of Analysis (COA) are provided, detailing results from tests such as HPLC assay, related substances, residual solvents, and heavy metals. We adhere to cGMP guidelines to ensure supply reliability and batch-to-batch consistency for our global partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5% w/w
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Sulfated Ash	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.