Description

Aprepitant CAS NO 1242175-36-5 is a high-purity active pharmaceutical ingredient (API) belonging to the class of neurokinin-1 (NK1) receptor antagonists. It is a critical component in the prevention of chemotherapy-induced nausea and vomiting (CINV), offering significant therapeutic value in oncology support care. This compound is essential for pharmaceutical manufacturers developing antiemetic formulations, including oral capsules and injectable solutions, for global healthcare markets.

Application

• Primary Active Pharmaceutical Ingredient (API) in antiemetic drugs for the prevention of acute and delayed nausea and vomiting associated with highly emetogenic cancer chemotherapy.
• Formulation Development for oral solid dosage forms, such as capsules, and for parenteral (injectable) formulations.
• Oncology Supportive Care, used in combination with other antiemetic agents (e.g., 5-HT3 antagonists and corticosteroids) in multi-day chemotherapy regimens.
• Research & Development for studying NK1 receptor pathways and developing next-generation antiemetic therapies.
• Reference Standard for quality control and analytical testing in pharmaceutical laboratories.

Basic Information

Product Name	Aprepitant
CAS No.	1242175-36-5
Molecular Formula	C23H21F7N4O3
Molecular Weight	534.43 g/mol
Synonyms	MK-0869; L-754,030; Emend (Brand Name); 5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-one; Neurokinin 1 Receptor Antagonist; Substance P Antagonist
EINECS	Contact for details

Quality Control

Our Aprepitant is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for pharmaceutical use, including identity, purity, and impurity profiles. Certificates of Analysis (COA) are provided, confirming compliance with relevant pharmacopeial standards (e.g., USP, EP) and internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time conforms to reference standard
Assay (HPLC)	98.0% - 102.0%
Related Substances (HPLC)	Individual impurity: NMT 0.5% Total impurities: NMT 1.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	< 20 ppm
Loss on Drying	< 1.0%
Sulfated Ash	< 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.