Description

(1S,2R,3R)-Aprepitant is a specific stereoisomer of the active pharmaceutical ingredient aprepitant, a potent and selective neurokinin-1 (NK1) receptor antagonist. This high-purity enantiomer is critical for pharmaceutical research and development, particularly in the formulation of targeted antiemetic therapies. It is primarily utilized by pharmaceutical manufacturers and advanced research institutions engaged in the synthesis of novel drug candidates for the prevention of chemotherapy-induced and postoperative nausea and vomiting.

Application

• Active Pharmaceutical Ingredient (API) for the synthesis of stereospecific antiemetic drugs.
• Key intermediate in advanced pharmaceutical research and process development.
• Reference standard for analytical method development and quality control in pharmaceutical laboratories.
• Building block for the investigation of neurokinin-1 receptor antagonist mechanisms in preclinical studies.
• Material for formulation studies of solid dosage forms such as capsules and tablets.

Basic Information

Item	Detail
Product Name	(1S,2R,3R)-Aprepitant
CAS No.	1242175-34-3
Molecular Formula	C23H21F7N4O3
Molecular Weight	534.43 g/mol
Synonyms	(1S,2R,3R)-5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1H-1,2,4-triazol-3-one; (1S,2R,3R)-Aprepitant; Aprepitant Isomer; L-754030 Isomer; MK-0869 Isomer; Emend® API Isomer; Neurokinin-1 Receptor Antagonist Isomer
EINECS	Contact for details

Quality Control

Our (1S,2R,3R)-Aprepitant is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and stereochemical integrity, aligning with ICH guidelines. A Certificate of Analysis (COA) detailing results for chiral purity, assay, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	≥ 98.5%
Chiral Purity (Chiral HPLC)	≥ 99.0%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.