Description

16α-Hydroxyestrone-[2,3,4-13C3] is a stable isotope-labeled analog of the endogenous estrogen metabolite 16α-hydroxyestrone. This compound is specifically enriched with carbon-13 at the 2, 3, and 4 positions, making it an essential tool for precise quantitative analysis in mass spectrometry. It serves as a critical internal standard for researchers and laboratories requiring high-accuracy measurements of estrogen metabolism and related biochemical pathways. The product is vital for applications in clinical diagnostics, endocrinology research, and pharmaceutical development where isotopic purity and structural fidelity are paramount.

Application

• Internal Standard for LC-MS/MS: Used as a quantitative reference standard in liquid chromatography-tandem mass spectrometry for the accurate measurement of 16α-hydroxyestrone and related metabolites in biological matrices.
• Endocrine Research: Facilitates studies on estrogen metabolism, hormone-dependent cancers, and the role of 16α-hydroxyestrone in various disease states.
• Clinical Diagnostics: Enables the development and validation of high-precision diagnostic assays for hormonal imbalance and metabolic disorders.
• Pharmaceutical Development: Employed in pharmacokinetic and pharmacodynamic studies during drug development targeting estrogen pathways.
• Metabolomics: Serves as a labeled tracer in metabolomic profiling to elucidate specific metabolic fluxes and pathways.
• Quality Control: Acts as a certified reference material for the calibration of analytical instruments and verification of method accuracy in testing laboratories.

Basic Information

Product Name	16α-Hydroxyestrone-[2,3,4-13C3]
CAS No.	1241684-28-5
Molecular Formula	C18H2213C3O3
Molecular Weight	~289.4 g/mol
Synonyms	16α-Hydroxyestrone-2,3,4-13C3; 16α-Hydroxy-1,3,5(10)-estratrien-3-ol-17-one-2,3,4-13C3; [2,3,4-13C3]-16α-Hydroxyestrone; 16α-Hydroxyestrone (13C3); Labeled 16α-Hydroxyestrone; Estrogen Metabolite Internal Standard; 16α-OHE1-13C3; 16α-Hydroxyoestrone-13C3
EINECS	Contact for details

Quality Control

Every batch of 16α-Hydroxyestrone-[2,3,4-13C3] is produced and analyzed under strict quality management protocols to ensure the highest isotopic and chemical purity. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, providing detailed data on isotopic enrichment, chemical purity, and identity confirmation via advanced spectroscopic methods.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or Certificate of Analysis. Keep the container in a dry, cool, and well-ventilated area. For long-term storage, consider storing at -20°C under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99 atom % 13C
Isotopic Purity (MS)	≥ 99% 13C3
Chemical Purity	≥ 95%
Solubility	Soluble in DMSO, Methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.