Description

11-Dehydro Thromboxane B2-D4 is a high-purity, stable isotope-labeled (deuterated) analog of a key thromboxane metabolite. This compound is essential as a critical internal standard for the precise quantification of thromboxane B2 and related eicosanoids in complex biological matrices using mass spectrometry. It is primarily required by pharmaceutical R&D laboratories, clinical research organizations, and academic institutions engaged in lipidomics, inflammation studies, and cardiovascular disease research to ensure analytical accuracy and data reliability.

Application

• Quantitative Mass Spectrometry: Serves as an indispensable internal standard for the accurate LC-MS/MS analysis of thromboxane B2 and its metabolites in plasma, serum, urine, and tissue samples.
• Biomarker Research: Enables precise measurement of thromboxane generation as a biomarker for platelet activation, oxidative stress, and inflammatory processes in cardiovascular and renal diseases.
• Drug Development & Pharmacology: Used in pharmacokinetic and pharmacodynamic studies to evaluate the efficacy of antiplatelet drugs (e.g., COX inhibitors, thromboxane synthase inhibitors) and novel therapeutics.
• Clinical Diagnostics: Supports the development and validation of robust clinical assays for monitoring thromboxane pathways in patient populations.
• Eicosanoid Profiling: A key component in comprehensive lipid mediator panels for systems biology approaches to understanding inflammation and resolution.
• Quality Control & Method Validation: Critical for establishing and maintaining GLP/GCP-compliant analytical methods in regulated bioanalytical laboratories.

Basic Information

Product Name	11-Dehydro Thromboxane B2-D4
CAS No.	1240398-15-5
Molecular Formula	C₂₀H₂₈D₄O₆
Molecular Weight	372.48 g/mol
Synonyms	11-Dehydro-TXB2-d4; 11-Dehydrothromboxane B2-d4; 2,3-Dinor-TXB2-d4; 11-Dehydro-thromboxane B2 (tetradeuterated); 11-Dehydro-TXB2 (D4); 11-Dehydro-9,11-dihydroxythromboxa-5,13-dien-1-oic acid-d4; Deuterated 11-Dehydro Thromboxane B2; Internal Standard for Thromboxane B2 Analysis
EINECS	Contact for details

Quality Control

Our 11-Dehydro Thromboxane B2-D4 is manufactured under strict quality systems to ensure the high purity and isotopic enrichment required for sensitive bioanalytical applications. Each batch is characterized by advanced analytical techniques including NMR, HPLC, and mass spectrometry to confirm chemical identity, isotopic purity (>98% D), and chromatographic performance. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and solvent content is provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Purity (D4)	≥ 98%
Chemical Purity (by NMR)	≥ 90%
Water Content (KF)	≤ 5.0%
Solvent Content (Residual Solvents)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.