Description

Guanosine, 3'-o-[(1,1-Dimethylethyl)Dimethylsilyl]-n-(2-Methyl-1-Oxopropyl)- is a chemically modified nucleoside derivative, specifically designed as a key protected intermediate in sophisticated organic synthesis. Its value lies in providing precise control over molecular structure during the construction of complex biomolecules, ensuring high regioselectivity and yield. This compound is critically needed by researchers and manufacturers in the pharmaceutical and biotechnology sectors for developing novel therapeutics, including oligonucleotides and antiviral agents.

Application

• Oligonucleotide Synthesis: Serves as a crucial, protected building block for the solid-phase synthesis of DNA and RNA analogs.
• Antiviral Drug Development: Used in the research and production of nucleoside-based antiviral compounds targeting various viruses.
• Pharmaceutical Intermediates: Acts as a high-purity intermediate in the multi-step synthesis of active pharmaceutical ingredients (APIs).
• Biochemical Research: Employed in academic and industrial labs for studying nucleic acid chemistry, enzyme mechanisms, and as a probe substrate.
• Prodrug Synthesis: Utilized to create prodrug forms of nucleoside analogs, enhancing their bioavailability and therapeutic profile.
• Labeled Compound Preparation: A starting point for synthesizing isotopically labeled (e.g., 13C, 15N) guanosine derivatives for metabolic tracing and imaging studies.

Basic Information

Product Name	Guanosine, 3'-o-[(1,1-Dimethylethyl)Dimethylsilyl]-n-(2-Methyl-1-Oxopropyl)-
CAS No.	1237684-87-5
Molecular Formula	C20H33N5O6Si
Molecular Weight	467.60 g/mol
Synonyms	3'-O-(tert-Butyldimethylsilyl)-N-isobutyryl-guanosine; N2-Isobutyryl-3'-O-(tert-butyldimethylsilyl)guanosine; Guanosine, 3'-O-[(1,1-dimethylethyl)dimethylsilyl]-N-(2-methyl-1-oxopropyl)-; 3'-O-TBDMS-N2-ibu-Guanosine; 3'-O-(tert-Butyldimethylsilyl)-2'-deoxy-N2-isobutyrylguanosine (common naming variant); TBDMS-G(Ibu) (abbreviation); Protected Guanosine Derivative; 3'-TBDMS-N2-isobutyryl Guanosine
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, purity, and stability. Certificates of Analysis (COA) detailing all specifications are available upon request. We adhere to a cGMP-compliant quality management system suitable for pharmaceutical intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.