Description

n-[4-[[(2,4-Diamino-6-Pteridinyl)Methyl]Amino]Benzoyl]Glutamic Acid is a high-purity, advanced pharmaceutical intermediate and reference standard. This compound is critical for research and development in the synthesis of novel folate analogs and targeted therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions focused on oncology and metabolic pathway research. The product is supplied with full traceability and stringent quality control to ensure reliable and reproducible results in sensitive applications.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel antifolate drugs and targeted chemotherapeutic agents.
• Biochemical Research: Used as a reference standard and precursor in studies of folate metabolism, enzyme inhibition, and cellular uptake mechanisms.
• Analytical Standard: Serves as a high-purity calibrant for HPLC, LC-MS, and other analytical methods in quality control and method development.
• Academic & Discovery Chemistry: Essential for medicinal chemistry programs exploring structure-activity relationships (SAR) of pteridine-based compounds.
• API Development: Employed in the development and scale-up processes for active pharmaceutical ingredients (APIs) targeting specific enzymatic pathways.

Basic Information

Product Name	n-[4-[[(2,4-Diamino-6-Pteridinyl)Methyl]Amino]Benzoyl]Glutamic Acid
CAS No.	1236566-87-2
Molecular Formula	C19H21N9O5
Molecular Weight	455.43 g/mol
Synonyms	4-[[(2,4-Diaminopteridin-6-yl)methyl]amino]benzoyl-L-glutamic Acid; Pteroic Acid Glutamate Derivative; N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic Acid; Folate Analog Intermediate; PTGA; L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-
EINECS	Contact for details

Quality Control

Every batch of n-[4-[[(2,4-Diamino-6-Pteridinyl)Methyl]Amino]Benzoyl]Glutamic Acid is manufactured and tested under a strict quality management system. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with exacting standards for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.