Description

Folic Acid Peg Dspe CAS NO 1236288-25-7 is a high-purity, functionalized polyethylene glycol (PEG) derivative, specifically engineered by conjugating folic acid to a DSPE-PEG backbone. This compound is critical for creating targeted drug delivery systems, as the folic acid moiety acts as a ligand for selective binding to folate receptor-overexpressing cells. It is an essential material for pharmaceutical R&D and advanced formulation scientists working in oncology, diagnostics, and nanomedicine.

Application

• Targeted Drug Delivery Systems: As an active targeting component for liposomes, nanoparticles, and micelles to enhance accumulation in cancer tissues.
• Diagnostic Agent Conjugation: For attaching imaging agents (e.g., fluorescent dyes, MRI contrast agents) to create targeted diagnostics.
• Surface Functionalization: To impart stealth properties and active targeting capabilities to nanocarriers, improving circulation time and efficacy.
• Pharmaceutical Research: A key reagent in pre-clinical studies for evaluating folate-receptor-mediated uptake and biodistribution.
• Bioconjugation & Linker Chemistry: Serves as a versatile heterobifunctional linker for attaching therapeutic payloads to targeting vectors.

Basic Information

Product Name	Folic Acid Peg Dspe
CAS No.	1236288-25-7
Molecular Formula	Contact for details
Molecular Weight	Variable (PEG chain length dependent)
Synonyms	1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[folate(polyethylene glycol)]; DSPE-PEG-Folate; Folic Acid-DSPE-PEG; Folate-PEG-DSPE; 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)]-Folate; PEG-DSPE-FA; FA-PEG-DSPE; Phospholipid-PEG-Folate
EINECS	Contact for details

Quality Control

Our Folic Acid Peg Dspe is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and conjugation efficiency, NMR for structural confirmation, and MS for molecular weight verification. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with your research and cGMP-grade application requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant for long-term stability. This material is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	Yellow to orange solid or film
Identification (HPLC/MS)	Complies
Purity (HPLC)	≥ 95%
Folic Acid Substitution	≥ 85%
DSPE Content	Reported
PEG Average Molecular Weight	2000, 3400, 5000 (or as requested)
Solubility	Soluble in chloroform, DMSO; forms micelles in water
Residual Solvents	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.