Description

Propargyl-Peg5-Mes CAS NO 1233816-83-5 is a heterobifunctional polyethylene glycol (PEG) linker featuring a propargyl group and a methyl ester (Mes) terminus, designed for efficient bioconjugation and materials science applications. This compound is a critical reagent for click chemistry, enabling the site-specific modification of biomolecules, polymers, and surfaces under mild, aqueous conditions. It is essential for researchers and manufacturers in pharmaceutical development, proteomics, and advanced material synthesis who require reliable, high-purity linkers to create stable, functionalized constructs.

Application

• Bioconjugation and ADC Development: Site-specific coupling of cytotoxic drugs, fluorescent dyes, or proteins to antibodies via copper-catalyzed azide-alkyne cycloaddition (CuAAC).
• PEGylation Reagent: Modification of therapeutic peptides, proteins, and oligonucleotides to enhance solubility, stability, and pharmacokinetic profiles.
• Polymer and Dendrimer Synthesis: Building block for creating functionalized, branched, or cross-linked polymeric architectures with tailored properties.
• Surface Functionalization: Grafting onto nanoparticles, biosensors, or chromatography media to introduce reactive alkyne handles for further immobilization.
• Chemical Biology Probes: Synthesis of activity-based probes (ABPs) or affinity tags for target identification and validation in proteomic studies.
• Hydrogel Formation: Cross-linking agent for creating biocompatible hydrogels with controlled mesh sizes for drug delivery or tissue engineering.
• Diagnostic Assay Development: Conjugation of detection molecules (e.g., enzymes, haptens) in lateral flow assays or ELISA platforms.

Basic Information

Product Name	Propargyl-Peg5-Mes
CAS No.	1233816-83-5
Molecular Formula	C20H36O9
Molecular Weight	420.5 g/mol
Synonyms	Propargyl-PEG5-methyl ester; 2,5,8,11,14-Pentaoxaheptadec-16-ynoic acid, methyl ester; Methyl-PEG5-propargyl; mPEG5-Alkyne; Methyl ester of Propargyl-PEG5-acid; Alkyne-PEG5-Mes; Propargyl-PEG5-acid methyl ester; Propargyl-PEG5-COOCH3
EINECS	Contact for details

Quality Control

Our Propargyl-Peg5-Mes is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with detailed specifications upon request. Our quality commitment aligns with the standards required for research and cGMP manufacturing environments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C to -10°C under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a dry environment before opening to prevent condensation and hydrolysis. For long-term storage, keep under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.