Description

19-(2,5-Dihydro-2,5-Dioxo-1H-Pyrrol-1-Yl)-19-Oxo-4,7,10,13,16-Pentaoxanonadecanoic Acid 2,5-Dioxo-1-Pyrrolidinyl Ester is a heterobifunctional, amine-reactive crosslinking agent featuring a hydrophilic polyethylene glycol (PEG) spacer and an activated ester terminus. This compound is engineered to facilitate the conjugation of biomolecules, offering enhanced solubility and reduced non-specific binding in aqueous systems. It is a critical reagent for researchers and manufacturers in bioconjugation, pharmaceutical development, and advanced material science, where precise and stable covalent linkages are required.

Application

• Bioconjugation and Protein Modification: Primary application for crosslinking peptides, proteins, and antibodies with other molecules or surfaces.
• PEGylation Reagent: Used to attach polyethylene glycol chains to therapeutic proteins to improve pharmacokinetics and reduce immunogenicity.
• Surface Functionalization: For modifying nanoparticles, biosensors, and diagnostic assay platforms with amine-reactive groups.
• Hydrogel and Biomaterial Synthesis: Acts as a crosslinker in the creation of biocompatible polymers and scaffolds for tissue engineering.
• Drug-Delivery System Development: Enables the covalent attachment of targeting ligands or drugs to carrier systems.
• Diagnostic Reagent Manufacturing: Used in the production of enzyme conjugates and labeled antibodies for ELISA and other immunoassays.

Basic Information

Product Name	19-(2,5-Dihydro-2,5-Dioxo-1H-Pyrrol-1-Yl)-19-Oxo-4,7,10,13,16-Pentaoxanonadecanoic Acid 2,5-Dioxo-1-Pyrrolidinyl Ester
CAS No.	1232769-29-7
Molecular Formula	C23H32N2O12
Molecular Weight	528.51 g/mol
Synonyms	NHS-PEG5-MAL; Maleimide-PEG5-NHS ester; SM(PEG)5; 4,7,10,13,16-Pentaoxanonadecanedioic acid, 19-[(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)oxy]-19-oxo-, 2,5-dioxo-1-pyrrolidinyl ester; PEG5 crosslinker; NHS-PEG-Maleimide (MW 500); Heterobifunctional PEG crosslinker, NHS-PEG5-Maleimide; 1-{19-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-19-oxo-4,7,10,13,16-pentaoxanonadecanoyl}-1H-pyrrole-2,5-dione
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch is characterized by HPLC, NMR, and mass spectrometry to confirm identity, purity, and functional group integrity. Certificates of Analysis (COA) with detailed specifications are provided to support your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and reactivity. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Functional Group Substitution	≥ 90% (NMR)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.