Description

(S)-α-Allylglycine Ethyl Ester p-Toluenesulfonate, 98% Ee is a high-purity, non-proteinogenic amino acid derivative, specifically the tosylate salt of the ethyl ester of (S)-α-allylglycine. This compound is a critical chiral building block valued for its high enantiomeric excess, enabling the synthesis of complex molecules with precise stereochemical control. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers in the development of active pharmaceutical ingredients (APIs), peptidomimetics, and novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents, particularly in central nervous system (CNS) and metabolic disorder drug candidates.
• Peptide Chemistry: Used in the solid-phase and solution-phase synthesis of modified peptides and peptidomimetics to introduce the unique α-allylglycine side chain.
• Asymmetric Synthesis: Serves as a versatile precursor for asymmetric transformations, including cross-metathesis and other C-C bond-forming reactions, to create complex chiral architectures.
• Chemical Biology Probes: Employed in the design and synthesis of enzyme inhibitors, receptor ligands, and other molecular probes for biochemical and pharmacological studies.
• Agrochemical Research: Potential application as a chiral intermediate in the synthesis of advanced, enantiomerically pure agrochemicals.
• Academic & Industrial R&D: A valuable reagent for methodological development in organic chemistry and catalysis within university and corporate research laboratories.

Basic Information

Product Name	(S)-α-Allylglycine Ethyl Ester p-Toluenesulfonate, 98% Ee
CAS No.	1231709-21-9
Molecular Formula	C15H21NO5S
Molecular Weight	327.40 g/mol
Synonyms	(S)-2-Amino-4-pentenoic Acid Ethyl Ester p-Toluenesulfonate; (S)-α-Allylglycine Ethyl Ester Tosylate; (S)-Ethyl 2-amino-4-pentenoate p-Toluenesulfonate; (S)-Ethyl 2-amino-4-pentenoate Tosylate Salt; (S)-2-Amino-4-pentenoic Acid Ethyl Ester Tosylate Salt; (S)-Ethyl 2-Amino-4-pentenoate 4-Methylbenzenesulfonate; (S)-Ethyl α-Amino-4-pentenoate p-Toluenesulfonate
EINECS	Contact for details

Quality Control

Our (S)-α-Allylglycine Ethyl Ester p-Toluenesulfonate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (Ee) verification, NMR for structural confirmation, and purity assessment. A Certificate of Analysis (COA) detailing identity, purity, and chiral purity is provided with every shipment to ensure traceability and compliance with your research and production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Ee)	≥ 98%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.