Description

n-(2-Aminoethyl)-Biotinamide is a high-purity, functionalized biotin derivative designed for advanced biochemical conjugation and research applications. This compound is critical for creating stable, high-affinity linkages with various biomolecules, enabling precise targeting and detection in complex systems. It is primarily utilized by researchers and manufacturers in the pharmaceutical, diagnostic, and life science sectors for developing novel therapeutics, assay kits, and affinity purification systems.

Application

• Bioconjugation Reagent: Used for the site-specific labeling of proteins, antibodies, and peptides to create biotinylated probes for detection and purification.
• Diagnostic Assay Development: A key component in the manufacture of ELISA, lateral flow assays, and other immunoassays that utilize streptavidin-biotin technology for signal amplification.
• Affinity Chromatography: Serves as a linker for immobilizing ligands onto solid supports (e.g., agarose beads) for the purification of target biomolecules.
• Drug Delivery Systems: Employed in the research and development of targeted drug conjugates and antibody-drug conjugates (ADCs).
• Cell Surface Labeling: Facilitates the tagging of cell surface receptors and other membrane proteins for flow cytometry and microscopy studies.
• Molecular Biology Research: Used in techniques like pull-down assays, chromatin immunoprecipitation (ChIP), and nucleic acid detection.
• Material Science: Functionalization of nanoparticles and other nanomaterials for biomedical imaging and sensing applications.

Basic Information

Product Name	n-(2-Aminoethyl)-Biotinamide
CAS No.	1231488-78-0
Molecular Formula	C12H22N4O2S
Molecular Weight	286.40 g/mol
Synonyms	Biotin-PE; Biotinamidoethylamine; Biotin ethylenediamine; N-Biotinyl-1,2-ethanediamine; 5-[(3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]-N-(2-aminoethyl)pentanamide; Biotin-EDA; 2-(5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)ethan-1-aminium
EINECS	Contact for details

Quality Control

Our n-(2-Aminoethyl)-Biotinamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and specific tests for residual solvents and moisture content. We provide comprehensive Certificates of Analysis (COA) with each shipment, ensuring traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.