Description

Dorzolamide CAS NO 1227097-70-2 is a potent and selective carbonic anhydrase inhibitor. This compound is of significant commercial and therapeutic importance as a key active pharmaceutical ingredient (API). It is primarily required by pharmaceutical manufacturers and research institutions for the development and production of ophthalmic solutions used in the management of elevated intraocular pressure, such as in glaucoma.

Application

• Ophthalmic Pharmaceutical Formulations: Primary use as the active ingredient in prescription eye drops for treating open-angle glaucoma and ocular hypertension.
• Drug Substance Manufacturing: Serves as the bulk API for pharmaceutical companies producing finished dosage forms under Good Manufacturing Practice (GMP) standards.
• Combination Therapies: Used in fixed-dose combination products with other agents like timolol for enhanced therapeutic efficacy.
• Pharmacological Research: Employed in biochemical and pharmacological studies to investigate carbonic anhydrase inhibition mechanisms and structure-activity relationships.
• Reference Standard: Utilized as a high-purity chemical reference standard in analytical laboratories for quality control and method validation.
• New Drug Development: Acts as a lead compound or intermediate in research programs aimed at developing novel therapeutics for related indications.

Basic Information

Product Name	Dorzolamide
CAS No.	1227097-70-2
Molecular Formula	C10H16N2O4S3
Molecular Weight	324.40 g/mol
Synonyms	(4S,6S)-4-(Ethylamino)-5,6-dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide; L-671,152; MK-0507; Dorzolamide Hydrochloride (salt form); Trusopt (brand name); Dorzolamidum; Dorzolamida; (4S-trans)-4-(Ethylamino)-5,6-dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide
EINECS	Contact for details

Quality Control

Our Dorzolamide is manufactured under strict quality systems. We provide material that meets or exceeds relevant pharmacopeial standards, including USP and EP monographs where applicable. Every batch undergoes comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling via advanced techniques like HPLC. Certificates of Analysis (COA) documenting all test results are available upon request to ensure full traceability and compliance for your regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a low-humidity environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 1.0% Any individual impurity ≤ 0.5%
Optical Rotation	Specific range provided on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.