Description

Granisetron Hydrochloride is a high-purity active pharmaceutical ingredient (API) belonging to the class of selective 5-HT3 receptor antagonists. This compound is critical for the prevention and treatment of chemotherapy-induced and post-operative nausea and vomiting (CINV and PONV). It is essential for pharmaceutical manufacturers developing injectable solutions, oral tablets, and other dosage forms requiring a reliable and potent antiemetic agent.

Application

• Primary API in the formulation of injectable antiemetic solutions for intravenous or intramuscular administration.
• Core ingredient in the production of oral tablets and capsules for patient self-administration post-chemotherapy.
• Used in pharmaceutical research and development for new antiemetic drug delivery systems.
• Critical component in the manufacture of generic oncology-supportive medications.
• Potential use in veterinary pharmaceuticals for managing nausea in animals.
• Reference standard in analytical laboratories for quality control and method validation.

Basic Information

Product Name	Granisetron Hydrochloride
CAS No.	1224925-76-1
Molecular Formula	C18H25ClN4O • HCl
Molecular Weight	393.78 g/mol (as hydrochloride salt)
Synonyms	Granisetron HCl; 1-Methyl-N-((1R,3r,5S)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl)-1H-indazole-3-carboxamide hydrochloride; BRL 43694A; Kytril (brand name analog); Sancuso (brand name analog); 5-HT3 receptor antagonist; Antiemetic API
EINECS	Contact for details

Quality Control

Our Granisetron Hydrochloride is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for pharmaceutical use, including identity, purity, and impurity profiles. Certificates of Analysis (COA) documenting compliance with relevant pharmacopeial standards (such as USP/EP) are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.