Description

5β-Androstan-3α,17β-Diol-2,2,3,4,4-D5 is a high-purity, deuterium-labeled analog of the endogenous steroid 5β-androstan-3α,17β-diol, serving as a critical internal standard for precise analytical quantification. This compound is essential for ensuring accuracy and reliability in mass spectrometry-based assays, particularly in clinical research and pharmaceutical development. It is primarily used by analytical laboratories, contract research organizations (CROs), and pharmaceutical companies engaged in steroid hormone analysis, metabolomics studies, and drug metabolism and pharmacokinetics (DMPK) research.

Application

• Internal Standard for LC-MS/MS: Used as a deuterated internal standard for the accurate quantification of 5β-androstan-3α,17β-diol and related steroid metabolites in biological matrices like serum, plasma, and urine.
• Clinical Diagnostics & Research: Supports research into endocrine disorders, congenital adrenal hyperplasia (CAH), and other conditions involving androgen metabolism pathways.
• Pharmaceutical DMPK Studies: Facilitates precise tracking of steroid drug metabolites in absorption, distribution, metabolism, and excretion (ADME) studies.
• Metabolomics & Biomarker Discovery: Enables high-fidelity profiling of steroid signatures in disease state versus healthy control studies.
• Forensic Toxicology: Aids in the confirmatory analysis of anabolic steroids and their metabolites in anti-doping and forensic investigations.
• Reference Standard: Serves as a certified reference material (CRM) for method development, validation, and laboratory quality control (QC) protocols.

Basic Information

Product Name	5β-Androstan-3α,17β-Diol-2,2,3,4,4-D5
CAS No.	1224710-37-5
Molecular Formula	C19H25D5O2
Molecular Weight	~295.5 g/mol
Synonyms	5β-Androstane-3α,17β-diol-d5; 3α,17β-Dihydroxy-5β-androstane-2,2,3,4,4-d5; Etiocholanediol-d5; 5β-Androstan-3α,17β-diol (2,2,3,4,4-d5); Deuterated 5β-Androstanediol; [2,2,3,4,4-2H5]-5β-Androstan-3α,17β-diol; Androstanediol-d5; 3α,17β-Androstanediol-d5
EINECS	Contact for details

Quality Control

Every batch of our deuterated standards is produced and analyzed under strict quality management systems. Certificates of Analysis (COA) are provided, detailing critical parameters such as isotopic purity (≥98 atom % D), chemical purity (by HPLC), and identity confirmation (by NMR and MS). Our quality commitment ensures traceability and reliability for your most demanding analytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider desiccant and under inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity	≥98 atom % D
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.