Description

Doxofylline-D6 (Dimethyl-D6) is a deuterated analog of the xanthine derivative doxofylline, specifically labeled with six deuterium atoms on the two methyl groups. This stable isotope-labeled compound is an essential internal standard for the precise quantification of doxofylline in complex biological matrices using advanced analytical techniques like LC-MS/MS. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in pharmacokinetic studies, bioequivalence testing, and metabolic research.

Application

• Internal Standard for Bioanalysis: Critical for accurate quantification of doxofylline in plasma, serum, and urine samples via mass spectrometry.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables reliable tracking of drug absorption, distribution, metabolism, and excretion (ADME).
• Drug Metabolism and Metabolite Identification: Used as a tracer to study metabolic pathways and identify metabolites.
• Clinical Trial Support: Ensures data integrity in bioanalytical assays conducted during human clinical trials.
• Method Development and Validation: Serves as a key component in developing and validating robust, regulatory-compliant analytical methods.
• Quality Control in Manufacturing: Can be utilized in impurity profiling and stability-indicating assay methods for doxofylline API.

Basic Information

Product Name	Doxofylline-D6 (Dimethyl-D6)
CAS No.	1219805-99-8
Molecular Formula	C11H8D6N4O4
Molecular Weight	272.29 g/mol
Synonyms	7-(1,3-Dioxolan-2-ylmethyl)-1,3-dimethyl-2,3,6,7,8,9-hexahydro-1H-purine-2,6-dione-d6; Doxofylline (dimethyl-d6); 1,3-Dimethyl-7-(1,3-dioxolan-2-ylmethyl)-3,7-dihydro-1H-purine-2,6-dione-d6; Ansimar-d6; Doxofilina-d6; (RS)-Doxofylline-d6; Deuteration at both N-methyl groups; Doxofylline Internal Standard
EINECS	Contact for details

Quality Control

Every batch of Doxofylline-D6 (Dimethyl-D6) is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and isotopic enrichment meet the highest standards for research use. Our quality commitment includes comprehensive characterization by NMR, HPLC, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific data including chemical purity, isotopic purity (D-enrichment), and residual solvent levels.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Chemical Purity (by NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.