Description

Biopterin-D3 is a deuterium-labeled isotopologue of the essential pteridine derivative, Biopterin. This high-purity reference standard is critical for ensuring analytical accuracy and reliability in quantitative research. It is primarily utilized by pharmaceutical R&D, clinical diagnostic, and academic research laboratories for use as an internal standard in mass spectrometry-based assays. The compound enables precise quantification and metabolic pathway tracing in complex biological matrices.

Application

• Internal Standard for LC-MS/MS: Used for the accurate quantification of endogenous biopterin and related metabolites in bioanalytical method development and validation.
• Metabolic Pathway Tracing: Employed in deuterium-labeling studies to investigate the biosynthesis, turnover, and metabolic fate of pterins in biological systems.
• Clinical Diagnostics Research: Supports the development of sensitive assays for measuring biopterin levels, which are biomarkers for conditions such as phenylketonuria (PKU) and certain neurological disorders.
• Pharmaceutical R&D: Facilitates drug metabolism and pharmacokinetics (DMPK) studies for compounds interacting with folate or pterin-dependent pathways.
• Quality Control Reference: Serves as a certified reference material (CRM) for calibrating analytical instruments and verifying the purity of commercial biopterin products.

Basic Information

Product Name	Biopterin-D3
CAS No.	1217838-71-5
Molecular Formula	C9H8D3N5O3
Molecular Weight	240.23 g/mol
Synonyms	6-Biopterin-D3; (6R)-2-Amino-6-[(1R,2S)-1,2-dihydroxypropyl]-5,6,7,8-tetrahydropteridin-4(3H)-one-D3; L-erythro-Biopterin-D3; 6-L-erythro-Biopterin-D3; Deuterated Biopterin; Tetrahydrobiopterin-d3 Precursor; BH4-d3 Precursor
EINECS	Contact for details

Quality Control

Our Biopterin-D3 is manufactured under strict quality management systems. Each batch is characterized and tested to ensure high isotopic purity and chemical identity, with specifications typically meeting or exceeding research-grade standards. A comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (D, %), chemical purity (by HPLC), and identification data (NMR, MS) is provided with every shipment to support your compliance and traceability requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Purity (D)	≥ 98 atom % D
Water Content (KF)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.