Description

Biotinylamidoethyl]-Dithiomethylenemalonic Acid Bis(2-Aminoethanoic Acid) is a specialized, high-purity biochemical building block designed for advanced research and pharmaceutical development. This compound is valued for its unique bifunctional structure, incorporating a biotin moiety for affinity labeling and a cleavable disulfide linkage, enabling controlled release and conjugation strategies. It is primarily utilized by researchers and manufacturers in the life sciences sector for applications such as targeted drug delivery systems, diagnostic probe development, and advanced bioconjugation chemistry.

Application

• Bioconjugation Reagent: For site-specific labeling of proteins, antibodies, and peptides to create targeted diagnostic or therapeutic agents.
• Drug Delivery Systems: As a key linker in the synthesis of prodrugs and antibody-drug conjugates (ADCs), leveraging its cleavable disulfide bond for controlled payload release.
• Affinity Chromatography: Immobilization onto solid supports for the purification of biomolecules via the high-affinity biotin-streptavidin interaction.
• Diagnostic Assay Development: Synthesis of biotinylated probes and tracers used in ELISA, immunohistochemistry, and other detection platforms.
• Chemical Biology Research: As a tool compound for studying protein interactions, cellular uptake mechanisms, and signal transduction pathways.
• Nanoparticle Functionalization: Surface modification of nanoparticles for targeted imaging and therapy.

Basic Information

Product Name	Biotinylamidoethyl]-Dithiomethylenemalonic Acid Bis(2-Aminoethanoic Acid)
CAS No.	1217718-11-0
Molecular Formula	C₁₉H₃₀N₆O₈S₂
Molecular Weight	542.61 g/mol
Synonyms	Biotin-SS-EDTA; Biotinylated Disulfide EDTA; Biotin-EDTA Disulfide; N-(Biotinamidoethyl)-N'-(2-aminoethyl)-3,3'-dithiodipropionamide-N,N,N',N'-tetraacetic Acid; EDTA-SS-Biotin; Biotin-LC-SS-EDTA; 2-[2-[5-[(3aS,4S,6aR)-2-Oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]ethyl]disulfanyl-3-[bis(2-carboxymethylamino)ethylamino]-3-oxopropanoic acid
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and pharmaceutical intermediates. Each batch is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, purity, and structural integrity. Certificates of Analysis (COA) detailing all relevant specifications are available upon request. We adhere to a quality management system to ensure batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.