Description

Biotinylamidoethyl]-Dithiomethylenemalonic Acid Bis(3-Aminopropionic Acid) is a specialized, high-purity biochemical building block designed for advanced research and synthesis. This compound is valued for its unique bifunctional structure, which incorporates a biotin moiety and a cleavable disulfide linker, enabling precise bioconjugation and targeted delivery applications. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors for developing novel therapeutics, probes, and assay components.

Application

• Bioconjugation Reagent: For site-specific labeling of proteins, antibodies, and peptides with biotin tags.
• Drug Delivery Systems: As a key linker in the development of targeted prodrugs and antibody-drug conjugates (ADCs) with redox-sensitive release mechanisms.
• Diagnostic Assay Development: In the fabrication of biosensors, ELISA kits, and other immunoassay platforms requiring stable biotin-streptavidin interactions.
• Proteomics & Pull-Down Assays: For immobilizing bait proteins onto solid supports to study protein-protein interactions.
• Cell Surface Engineering: For modifying cell membranes with biotin groups to facilitate subsequent labeling or sorting.
• Material Science: Functionalization of nanoparticles and polymers for biomedical applications.

Basic Information

Product Name	Biotinylamidoethyl]-Dithiomethylenemalonic Acid Bis(3-Aminopropionic Acid)
CAS No.	1217630-39-1
Molecular Formula	C21H34N6O8S2
Molecular Weight	562.66 g/mol
Synonyms	Biotin-S-S-Malonic Acid-Bis(β-alanine); Biotin-Disulfide-Malonic Acid-Bis(3-aminopropanoic Acid); Biotinylated Disulfide Linker; Biotin-SS-Mal-Bis(β-Ala); (Biotinylamidoethyl)disulfanylmethylenepropanedioic acid bis(3-aminopropanoic acid); Biotin-HPDP-Bis(β-Alanine) analog; Biotinylated cleavable crosslinker; N-(6-(Biotinamido)hexyl)-3'-(2-pyridyldithio)propionamide derivative
EINECS	Contact for details

Quality Control

Our Biotinylamidoethyl]-Dithiomethylenemalonic Acid Bis(3-Aminopropionic Acid) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and specific tests for moisture and related substances. We provide comprehensive Certificates of Analysis (COA) with each shipment to ensure traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, moisture-free environment. Allow the sealed container to equilibrate to room temperature before opening to minimize condensation and moisture uptake. For long-term stability, store desiccated.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Disulfide Bond Integrity	≥ 98%
Solubility	Soluble in DMSO, DMF; Slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.