Description

3,3',5-Triiodothyronine-(Tyrosine Ring-13C6) Hydrochloride is a stable isotope-labeled analog of the thyroid hormone T3, where the tyrosine ring is enriched with carbon-13. This compound is essential as a high-purity internal standard in quantitative bioanalytical methods, ensuring unparalleled accuracy and reliability in mass spectrometry-based assays. It is primarily required by pharmaceutical R&D laboratories, clinical research organizations, and diagnostic manufacturers for pharmacokinetic studies, metabolic profiling, and the development of sensitive diagnostic tests.

Application

• Internal Standard for LC-MS/MS: Critical for the precise quantification of endogenous T3 levels in biological matrices (serum, plasma, tissue) for clinical and preclinical studies.
• Pharmaceutical R&D: Used in drug metabolism and pharmacokinetics (DMPK) studies to investigate compounds affecting thyroid hormone pathways.
• Endocrine Disorder Research: Facilitates accurate measurement of thyroid hormone concentrations in research related to hyperthyroidism, hypothyroidism, and thyroid cancer.
• Diagnostic Assay Development: Serves as a reference material in the calibration and validation of immunoassays and mass spectrometry-based clinical diagnostic kits.
• Metabolic Pathway Tracing: The 13C6-label allows for detailed studies of thyronine metabolism and conversion pathways in vitro and in vivo.
• Quality Control in Manufacturing: Employed as a reference standard in the quality control of pharmaceutical products containing thyroid hormones.

Basic Information

Product Name	3,3',5-Triiodothyronine-(Tyrosine Ring-13C6) Hydrochloride
CAS No.	1217473-60-3
Molecular Formula	C1513C6H11I3NO4 • HCl
Molecular Weight	~ 824.86 g/mol (for 13C6 isotopologue)
Synonyms	Liothyronine-(Tyrosine Ring-13C6) Hydrochloride; T3-(Tyrosine Ring-13C6) HCl; 3,3',5-Triiodo-L-thyronine-(Tyrosine Ring-13C6) Hydrochloride; [13C6]-T3 Hydrochloride; Isotopically Labeled T3 HCl; (S)-2-Amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoic Acid-(Ring-13C6) Hydrochloride; L-T3-(Tyrosine Ring-13C6) Hydrochloride
EINECS	Contact for details

Quality Control

Every batch of our 3,3',5-Triiodothyronine-(Tyrosine Ring-13C6) Hydrochloride is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive testing performed using advanced techniques like HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, isotopic enrichment, and other critical parameters to meet the stringent requirements of analytical and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99 atom % 13C
Chemical Purity	≥ 95%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.