Description

Quetiapine-D4 Hemifumarate is a stable isotope-labeled internal standard of the atypical antipsychotic quetiapine, specifically deuterated at four positions. This high-purity reference material is essential for ensuring the accuracy and reliability of quantitative bioanalytical methods, particularly Liquid Chromatography-Mass Spectrometry (LC-MS/MS). It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in pharmacokinetic studies, therapeutic drug monitoring, and metabolism research for quetiapine.

Application

• Quantitative Bioanalysis: Serves as a critical internal standard for the precise quantification of quetiapine in biological matrices (plasma, serum, urine) using LC-MS/MS.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables accurate measurement of drug concentration over time to study absorption, distribution, metabolism, and excretion (ADME).
• Therapeutic Drug Monitoring (TDM): Supports the development and validation of robust clinical assays to optimize quetiapine dosing for individual patients.
• Metabolite Identification and Profiling: Aids in distinguishing drug-derived metabolites from endogenous compounds in complex samples.
• Method Development and Validation: Used as a benchmark to establish selectivity, sensitivity, linearity, and accuracy of new analytical procedures according to FDA/ICH guidelines.
• Forensic and Clinical Toxicology: Facilitates the accurate detection and quantification of quetiapine in forensic investigations or overdose cases.
• Quality Control in Reference Material Production: Acts as a calibrant for certifying the purity and concentration of unlabeled quetiapine reference standards.

Basic Information

Product Name	Quetiapine-D4 Hemifumarate
CAS No.	1217310-65-0
Molecular Formula	C23H22D4N3O2S • 0.5C4H4O4
Molecular Weight	~434.55 g/mol (as hemifumarate salt)
Synonyms	2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol-D4 hemifumarate; Quetiapine-d4 fumarate (1:0.5); Seroquel-D4 hemifumarate; ICI 204,636-D4 hemifumarate; Quetiapine (tetradeuterated) hemifumarate; 11-[4-[2-(2-Hydroxyethoxy)ethyl]-1-piperazinyl]dibenzo[b,f][1,4]thiazepine-D4 hemifumarate
EINECS	Contact for details

Quality Control

Our Quetiapine-D4 Hemifumarate is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch undergoes comprehensive testing, including NMR (¹H, ¹³C) and Mass Spectrometry for structural and isotopic confirmation, and HPLC for chemical purity assessment. Certificates of Analysis (COA) detailing batch-specific results for assay, isotopic enrichment, and related substances are provided and traceable to in-house primary reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or CoA. The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98.0 atom % D
Chemical Purity	≥ 95.0% (by NMR)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.