Description

Disopyramide-D14 Tosylate Salt is a high-purity, isotopically labeled internal standard critical for ensuring accuracy and reliability in quantitative bioanalytical methods. This deuterated compound is specifically designed for use in Liquid Chromatography-Mass Spectrometry (LC-MS) and Gas Chromatography-Mass Spectrometry (GC-MS) applications, where it compensates for matrix effects and instrument variability. It is an essential tool for pharmaceutical research, clinical laboratories, and contract research organizations (CROs) conducting pharmacokinetic, metabolism, and doping control studies.

Application

• Quantitative Bioanalysis: Serves as a stable isotope-labeled internal standard for the precise quantification of Disopyramide in biological matrices (plasma, serum, urine) using LC-MS/MS or GC-MS.
• Pharmacokinetic & Metabolism Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Therapeutic Drug Monitoring (TDM): Used in clinical laboratories to develop and validate robust assays for monitoring Disopyramide levels in patient samples to ensure therapeutic efficacy and safety.
• Doping Control & Forensic Analysis: Supports method development for the detection and confirmation of Disopyramide in sports anti-doping and forensic toxicology investigations.
• Method Development & Validation: A key reagent for developing, optimizing, and validating new analytical methods in compliance with regulatory guidelines (e.g., FDA, EMA).
• Reference Material for Quality Control: Used as a certified reference material (CRM) to ensure the accuracy and traceability of analytical results within quality control laboratories.

Basic Information

Product Name	Disopyramide-D14 Tosylate Salt
CAS No.	1216989-88-6
Molecular Formula	C21H15D14N2O.C7H8O3S
Molecular Weight	~ 529.7 g/mol
Synonyms	Disopyramide-d14 4-Methylbenzenesulfonate; Disopyramide-d14 Tosylate; 4-Methylbenzenesulfonic acid compound with α-[2-[bis(1-methylethyl)amino]ethyl]-α-phenyl-2-pyridineacetamide-d14; Deuterated Disopyramide Tosylate; Disopyramide (phenyl-d5, piperidine-d9) Tosylate Salt; Norpace-d14 Tosylate; SC-7031-d14 Tosylate; Isotopically Labeled Disopyramide Internal Standard
EINECS	Contact for details

Quality Control

Every batch of Disopyramide-D14 Tosylate Salt is manufactured and analyzed under strict quality systems to ensure the highest standards of isotopic purity and chemical integrity. Our products undergo rigorous quality testing, including advanced spectroscopic and chromatographic techniques, to ensure compliance with industry standards for reference materials. Certificates of Analysis (COA) are provided with each shipment, detailing batch-specific results for isotopic enrichment, chemical purity, and identity confirmation.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Enrichment)	≥ 98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.