Description

Rizatriptan-D6 Benzoate is a deuterium-labeled internal standard of the active pharmaceutical ingredient Rizatriptan, a selective serotonin receptor agonist. This high-purity, isotopically labeled compound is essential for ensuring the accuracy and reliability of quantitative bioanalytical methods, particularly in pharmacokinetic and metabolism studies. It is a critical tool for pharmaceutical R&D, contract research organizations (CROs), and analytical laboratories requiring precise and sensitive LC-MS/MS or GC-MS analysis.

Application

• Internal Standard for Bioanalysis: Primary use as a quantitative reference standard in LC-MS/MS and GC-MS assays for Rizatriptan in biological matrices (plasma, serum, urine).
• Drug Metabolism and Pharmacokinetics (DMPK): Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical studies.
• Pharmaceutical Quality Control: Supports method development and validation for the assay of Rizatriptan in active pharmaceutical ingredients (APIs) and finished dosage forms.
• Clinical Research: Used in studies to monitor patient drug levels, assess bioavailability, and ensure therapeutic efficacy and safety.
• Forensic and Toxicology Testing: Aids in the precise identification and quantification of Rizatriptan in forensic analyses.

Basic Information

Product Name	Rizatriptan-D6 Benzoate
CAS No.	1216984-85-8
Molecular Formula	C22H20D6N6O2
Molecular Weight	408.51 g/mol
Synonyms	Rizatriptan-d6 Benzoate; 3-[2-(Dimethylamino)ethyl]-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-d6 Benzoate; MK-0462-d6 Benzoate; N,N-Dimethyl-5-[(1H-1,2,4-triazol-1-yl)methyl]-1H-indole-3-ethanamine-d6 Benzoate; Isotopically Labeled Rizatriptan Benzoate; Deuterated Rizatriptan Benzoate; Rizatriptan (phenyl-d5, methyl-d) Benzoate
EINECS	Contact for details

Quality Control

Our Rizatriptan-D6 Benzoate is manufactured under strict quality control protocols to ensure the highest standards of isotopic purity and chemical integrity. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and mass spectrometry, to confirm identity, chemical purity, and isotopic enrichment. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Isotopic Purity	≥98 atom % D
Chemical Purity	≥95%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.