Description

5-[2-Ethoxy-5-[4-(1,1,2,2,2-Pentadeuterioethyl)Piperazin-1-Yl]Sulfonylphenyl]-1-Methyl-3-Propyl-4H-Pyrazolo[4,3-D]Pyrimidin-7-One is a deuterated analog of a well-known phosphodiesterase type 5 (PDE5) inhibitor, where specific hydrogen atoms are replaced with deuterium. This deuteration is strategically employed to modify the pharmacokinetic and metabolic profile of the parent compound, offering significant advantages for research and development. It is a critical material for pharmaceutical companies and research institutions focused on drug metabolism studies, internal standards for bioanalytical assays, and the development of new chemical entities with improved properties.

Application

• Primary use as a deuterated internal standard for the precise quantification of the parent drug and its metabolites in biological matrices (e.g., plasma, serum) using LC-MS/MS.
• Essential tool in pharmacokinetic (PK) and drug metabolism studies to investigate absorption, distribution, metabolism, and excretion (ADME) profiles.
• Used in metabolite identification and structural elucidation research due to its isotopic labeling.
• Valuable for method development and validation in bioanalytical laboratories to ensure accuracy and regulatory compliance (e.g., FDA, EMA guidelines).
• Research into the isotope effect on drug stability, metabolic pathways, and receptor binding.
• Potential starting material or intermediate for the synthesis of novel deuterated pharmaceutical compounds.

Basic Information

Product Name	5-[2-Ethoxy-5-[4-(1,1,2,2,2-Pentadeuterioethyl)Piperazin-1-Yl]Sulfonylphenyl]-1-Methyl-3-Propyl-4H-Pyrazolo[4,3-D]Pyrimidin-7-One
CAS No.	1216711-61-3
Molecular Formula	C23H30D5N5O4S
Molecular Weight	~489.62 g/mol (deuterated form)
Synonyms	Deuterated Sildenafil-d5; Sildenafil-d5 (Ethyl-d5); 5-[2-Ethoxy-5-[4-(Ethyl-d5)piperazin-1-yl]sulfonylphenyl]-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one; UK-92480-d5; Deuterated PDE5 Inhibitor-d5; (Ethyl-d5)-Sildenafil; 1-[[3-(6,7-Dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl]-4-(ethyl-d5)piperazine
EINECS	Contact for details

Quality Control

This high-value deuterated compound is produced and controlled under strict quality management to ensure isotopic purity and chemical integrity, critical for its use as an analytical standard. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR (for deuterium incorporation), HPLC, and MS. A comprehensive Certificate of Analysis (COA) is provided, detailing assay purity, isotopic enrichment, and impurity profiles, supporting compliance with GLP/GMP principles for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (d5)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.