Description

Medetomidine-13C,D3 Hydrochloride is a high-purity, isotopically labeled internal standard critical for advanced analytical quantification. This compound is essential for ensuring the accuracy and reliability of mass spectrometry-based methods in pharmacokinetic and metabolic studies. It is primarily used by pharmaceutical researchers, contract research organizations (CROs), and analytical laboratories engaged in drug development and forensic toxicology.

Application

• Quantitative Bioanalysis: Serves as a stable isotope-labeled internal standard for the precise quantification of medetomidine and its metabolites in biological matrices (e.g., plasma, serum, urine) using LC-MS/MS and GC-MS.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Forensic and Clinical Toxicology: Used in method development and validation for the sensitive and specific detection of medetomidine in forensic investigations and clinical overdose cases.
• Metabolite Identification and Profiling: Aids in the structural elucidation and quantification of drug metabolites, facilitating a deeper understanding of metabolic pathways.
• Method Development and Validation: Critical for establishing robust, reproducible, and GLP-compliant analytical methods in regulated laboratory environments.
• Veterinary Pharmaceutical Research: Supports research into sedative and analgesic agents, given medetomidine's primary use in veterinary medicine.

Basic Information

Product Name	Medetomidine-13C,D3 Hydrochloride
CAS No.	1216630-06-6
Molecular Formula	C13H16D3ClN2 * 13C
Molecular Weight	Contact for details
Synonyms	4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole-13C,d3 Hydrochloride; Dexmedetomidine-13C,D3 Impurity; (S)-Medetomidine-13C,D3 Hydrochloride; Medetomidine-d3-13C HCl; Isotopically Labeled Medetomidine HCl; Medetomidine Internal Standard; 1216630-06-6; Domitor-13C,D3 (labeled analog)
EINECS	Contact for details

Quality Control

Every batch of Medetomidine-13C,D3 Hydrochloride is manufactured under strict quality management systems and undergoes comprehensive analytical characterization. Our products are supported by a detailed Certificate of Analysis (COA) that includes data for isotopic purity, chemical purity, and identity confirmation using techniques such as NMR, HPLC, and MS. We ensure compliance with the rigorous standards required for analytical reference materials in regulated research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity	≥99.0 atom % 13C; ≥98.0 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.