Description

Disulfiram-D20 is a deuterated isotopologue of the established pharmaceutical compound disulfiram, specifically designed for advanced research and development applications. This stable isotope-labeled version is critical for use as an internal standard in mass spectrometry-based analytical methods, ensuring unparalleled accuracy in quantitative analysis. It is primarily utilized by pharmaceutical researchers, analytical laboratories, and contract research organizations (CROs) engaged in pharmacokinetic studies, drug metabolism research, and high-precision quality control.

Application

• Internal Standard for LC-MS/MS: Serves as a critical reference compound in Liquid Chromatography-Tandem Mass Spectrometry for the precise quantification of disulfiram and its metabolites in biological matrices.
• Pharmacokinetic and Bioavailability Studies: Enables accurate tracking and measurement of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Drug Metabolism Research: Facilitates the identification and quantification of metabolic pathways and degradation products, aiding in the understanding of drug efficacy and safety profiles.
• Forensic and Clinical Toxicology: Used in assays to accurately determine disulfiram levels in forensic analysis or therapeutic drug monitoring programs.
• Pharmaceutical Quality Control: Supports method development and validation for the assay and impurity profiling of disulfiram in active pharmaceutical ingredients (APIs) and finished dosage forms.
• Isotope Dilution Mass Spectrometry (IDMS): Employed in this gold-standard technique for achieving the highest possible accuracy in quantitative measurements.

Basic Information

Product Name	Disulfiram-D20
CAS No.	1216403-88-1
Molecular Formula	C10H10D20N2S4
Molecular Weight	298.61 g/mol (approximate)
Synonyms	Tetraethylthiuram Disulfide-D20; Bis(diethylthiocarbamoyl) Disulfide-D20; Antabuse-D20; 1,1',1'',1'''-(Dithiodicarbonothioyl)tetrakis(1,1,2,2,2-pentadeuteroethane); TETD-D20; Thioperoxydicarbonic Diamide-D20; ((CH3CD2)2NC(S)S)2
EINECS	Contact for details

Quality Control

Our Disulfiram-D20 is manufactured under strict quality systems to ensure the high chemical and isotopic purity required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment (D-content), chemical purity by HPLC, and identification. We adhere to relevant industry standards for research chemicals, ensuring reliable and reproducible performance in your laboratory.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Isotopic Purity (D-content)	≥ 98 atom % D
Chemical Purity (HPLC)	≥ 98.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.