Description

Lidocaine-D6 Hcl is a deuterated internal standard of the widely used local anesthetic, Lidocaine Hydrochloride. This stable isotope-labeled compound is essential for ensuring the accuracy and reliability of quantitative mass spectrometry analyses. It is primarily utilized by analytical laboratories and research institutions in the pharmaceutical and forensic toxicology sectors for method development, validation, and routine testing.

Application

• Quantitative Bioanalysis: Serves as a critical internal standard in LC-MS/MS and GC-MS methods for the precise quantification of lidocaine and its metabolites in biological matrices (e.g., plasma, serum, urine).
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion in clinical and preclinical research.
• Forensic Toxicology: Used in confirmatory testing and accurate measurement of lidocaine concentrations in post-mortem and human performance toxicology cases.
• Drug Metabolism Research: Facilitates studies on the metabolic pathways and enzymatic transformation of lidocaine.
• Method Development & Validation: A key reagent for developing, optimizing, and validating robust analytical methods in compliance with regulatory guidelines (e.g., FDA, EMA).
• Quality Control in Pharmaceutical Manufacturing: Can be employed in impurity profiling and assay verification of lidocaine-containing drug products.

Basic Information

Product Name	Lidocaine-D6 Hcl
CAS No.	1215823-29-2
Molecular Formula	C14H16D6ClN2O • HCl
Molecular Weight	287.25 g/mol
Synonyms	Lidocaine-d6 Hydrochloride; 2-(Diethylamino-d10)-N-(2,6-dimethylphenyl)acetamide-d6 Hydrochloride; Lignocaine-d6 HCl; Xylocaine-d6 Hydrochloride; Deuterated Lidocaine HCl; Lidocaine Internal Standard (D6); [2H6]-Lidocaine Hydrochloride
EINECS	Contact for details

Quality Control

Our Lidocaine-D6 Hcl is manufactured under strict quality controls to ensure high chemical purity and isotopic enrichment, which are critical for its performance as an internal standard. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing specifications for isotopic purity, chemical purity (by HPLC), and identity confirmation (by NMR and MS). We support research and analysis requiring compliance with GLP and ISO 17025 standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98.0 atom % D
Chemical Purity	≥ 95.0% (by NMR)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.