Description

Butamirate-D5 Citrate is a deuterated citrate salt of the antitussive agent butamirate, specifically labeled with five deuterium atoms. This stable isotope-labeled compound is essential for high-precision analytical and research applications where metabolic tracing and quantification are critical. It is primarily utilized by pharmaceutical research and development laboratories, contract research organizations (CROs), and analytical service providers engaged in advanced pharmacokinetic, bioavailability, and drug metabolism studies.

Application

• Internal Standard for LC-MS/MS Analysis: Serves as a critical quantitative reference standard in bioanalytical methods for quantifying butamirate in biological matrices like plasma and urine.
• Pharmacokinetic and Metabolism Studies: Enables precise tracking and measurement of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Deuterium-Labeled Reference Material: Used as a certified reference material (CRM) for method development, validation, and ensuring regulatory compliance in bioanalysis.
• Drug Impurity Profiling: Aids in the identification and quantification of potential deuterated impurities or metabolites in pharmaceutical products.
• Stable Isotope Dilution Assays: Fundamental component in mass spectrometry-based assays requiring high accuracy and minimal matrix effects.

Basic Information

Product Name	Butamirate-D5 Citrate
CAS No.	1215650-08-0
Molecular Formula	C18H23D5N2O2 • C6H8O7
Molecular Weight	Contact for details
Synonyms	Butamirate-d5 Citrate; 2-(2-(Diethylamino)ethoxy)ethyl 2-phenylbutyrate-d5 Citrate; Butamyrate-d5 Citrate; Butamirate (pentadeutero) Citrate; Butamirate D5 Citrate Salt; Butamirate-d5 (1:1) Citrate; Butamirate Citrate-d5; [2H5]-Butamirate Citrate
EINECS	Contact for details

Quality Control

Our Butamirate-D5 Citrate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR (1H, 13C) and High-Resolution Mass Spectrometry (HRMS) for structural confirmation and isotopic purity assessment. Purity is determined via HPLC with stringent control over chemical and isotopic impurities. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert conditions (e.g., nitrogen atmosphere) after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Enrichment)	≥ 98.0 atom % D
Chemical Purity (by HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.