Description

Metopimazine CAS NO 1215315-86-8 is a high-purity pharmaceutical intermediate and active ingredient belonging to the phenothiazine class. It is primarily valued for its potent antiemetic properties, making it a critical component in the development and manufacturing of medications targeting nausea and vomiting. This compound is essential for pharmaceutical companies, research institutions, and fine chemical suppliers engaged in the synthesis of advanced therapeutic agents.

Application

• Pharmaceutical Active Ingredient (API): Primary use as the key component in the formulation of prescription antiemetic drugs.
• Clinical Research & Development: Utilized in preclinical and clinical studies for developing new treatments for chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea.
• Reference Standard: Serves as a certified reference material (CRM) for quality control and analytical method development in pharmaceutical laboratories.
• Veterinary Medicine: Potential application in veterinary pharmaceuticals for managing emesis in animals.
• Fine Chemical Synthesis: Used as a sophisticated building block for the synthesis of more complex phenothiazine derivatives and novel chemical entities.

Basic Information

Product Name	Metopimazine
CAS No.	1215315-86-8
Molecular Formula	C₂₂H₂₈N₂O₂S
Molecular Weight	384.54 g/mol
Synonyms	Metopimazine; Vogalene; 1-[3-[2-(Methylphenothiazin-10-yl)ethyl]piperid-1-yl]propan-1-one; 1-[3-[2-(Methyl-10H-phenothiazin-10-yl)ethyl]-1-piperidinyl]-1-propanone; 1-[3-[2-(N-Methylphenothiazin-10-yl)ethyl]piperidino]propan-1-one; RP 35567; Metopimazinum; Metopimazina
EINECS	Contact for details

Quality Control

Our Metopimazine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identification by spectroscopic methods, to ensure it meets stringent pharmaceutical-grade specifications. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance with your quality requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.