Description

Rolapitant (1S,2R,3R)-Isomer CAS NO 1214741-30-6 is a specific stereoisomer of the potent and selective neurokinin-1 (NK1) receptor antagonist, Rolapitant. This high-purity isomer is critical for pharmaceutical research and development, particularly in the formulation of antiemetic drugs. It is primarily sought by pharmaceutical manufacturers and advanced research institutions for the development and production of next-generation therapies to prevent chemotherapy-induced nausea and vomiting (CINV).

Application

• Active Pharmaceutical Ingredient (API) Intermediate: A key chiral building block in the synthesis of the finished Rolapitant API.
• Pharmaceutical R&D: Used in preclinical and clinical studies to investigate the efficacy and pharmacokinetics of stereospecific NK1 receptor antagonists.
• Reference Standard: Serves as a high-purity chromatographic and spectroscopic standard for quality control and analytical method development.
• Process Chemistry: Employed in route scouting and optimization for the scalable manufacturing of Rolapitant.
• Formulation Studies: Utilized in the development of stable and bioavailable dosage forms, such as tablets or injectables.

Basic Information

Product Name	Rolapitant (1S,2R,3R)-Isomer
CAS No.	1214741-30-6
Molecular Formula	C28H33F6N3O2
Molecular Weight	557.57 g/mol
Synonyms	(1S,2R,3R)-Rolapitant; Rolapitant Isomer; (5S,8S)-8-{[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]methyl}-8-phenyl-1,7-diazaspiro[4.5]decan-2-one; VARUBI Isomer; SCH 619734 Isomer; NK1 Receptor Antagonist Isomer
EINECS	Contact for details

Quality Control

Our Rolapitant (1S,2R,3R)-Isomer is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for stereochemical purity and identity confirmation by NMR and MS. We provide full traceability and Certificates of Analysis (COA) are supplied with every shipment, detailing purity, related substances, and residual solvents to meet the stringent requirements of pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Chiral Purity (Chiral HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤1.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.