Description

Rolapitant (1S,2S,3R)-Isomer is a specific stereoisomer of the potent and selective neurokinin-1 (NK1) receptor antagonist, Rolapitant. This high-purity isomer is critical for pharmaceutical research and development, particularly in the formulation of antiemetic drugs used to prevent chemotherapy-induced nausea and vomiting (CINV). It is essential for pharmaceutical manufacturers, advanced intermediates suppliers, and research institutions focused on developing and scaling up targeted therapeutic agents.

Application

• Active Pharmaceutical Ingredient (API) Intermediate: A key chiral building block in the synthesis of the finished Rolapitant API.
• Pharmaceutical R&D: Used in preclinical and clinical studies to investigate the efficacy and pharmacokinetics of the specific (1S,2S,3R) stereoisomer.
• Process Chemistry & Scale-Up: Serves as a critical reference standard and starting material for optimizing synthetic routes and manufacturing processes.
• Analytical Standard: Employed as a high-purity standard for method development and validation in quality control laboratories (e.g., HPLC, chiral analysis).
• Formulation Development: Used in studies to develop stable and bioavailable dosage forms, such as tablets or injectables.

Basic Information

Product Name	Rolapitant (1S,2S,3R)-Isomer
CAS No.	1214741-29-3
Molecular Formula	C28H33F6N3O2
Molecular Weight	557.57 g/mol
Synonyms	(1S,2S,3R)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholin-4-yl-1-phenylbutan-2-ol; (1S,2S,3R)-Rolapitant; Rolapitant Isomer; SCH 619734 Isomer; Varubi Intermediate; NK-1 Receptor Antagonist Isomer
EINECS	Contact for details

Quality Control

Our Rolapitant (1S,2S,3R)-Isomer is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including chiral purity by HPLC, to ensure it meets stringent specifications for pharmaceutical use. A Certificate of Analysis (COA) is provided with each shipment, detailing purity, identity, and impurity profiles. We support compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.5%
Chiral Purity (HPLC)	≥99.0% (1S,2S,3R)-Isomer
Related Substances (HPLC)	Total impurities ≤1.0% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.