Description

Rolapitant (1S,2R,3S)-Isomer is a specific stereoisomer of the potent and selective neurokinin-1 (NK1) receptor antagonist, Rolapitant. This high-purity intermediate is critical for the development and manufacturing of advanced antiemetic pharmaceuticals. It is primarily required by pharmaceutical R&D laboratories and API manufacturers focused on producing next-generation treatments for chemotherapy-induced nausea and vomiting (CINV).

Application

• Key chiral intermediate in the synthesis of the active pharmaceutical ingredient (API) Rolapitant.
• Research and development of novel NK1 receptor antagonist formulations.
• Process development and scale-up activities for GMP manufacturing of antiemetic drugs.
• Reference standard for analytical method development and quality control in pharmaceutical production.
• Building block for investigating structure-activity relationships (SAR) in neurokinin pathway research.

Basic Information

Product Name	Rolapitant (1S,2R,3S)-Isomer
CAS No.	1214741-28-2
Molecular Formula	C25H27F6N3O2
Molecular Weight	515.49 g/mol
Synonyms	(1S,2R,3S)-5-[(5,7-Difluoro-1,2,3,4-tetrahydro-2-naphthalenyl)oxy]-1,2,3,4-tetrahydro-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-1-(1-methyl-1H-1,2,4-triazol-5-ylmethyl)-3-phenylquinolinium; (1S,2R,3S)-Rolapitant Isomer; Rolapitant Stereoisomer; Rolapitant Intermediate; Varubi Intermediate; SCH 619734 Isomer
EINECS	Contact for details

Quality Control

Our Rolapitant (1S,2R,3S)-Isomer is manufactured under strict quality systems suitable for pharmaceutical development. Each batch is subjected to comprehensive analytical testing, including chiral HPLC for stereochemical purity and identity confirmation. Certificates of Analysis (COA) with detailed chromatographic data are provided to ensure traceability and compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC, Area %)	≥ 98.5%
Chiral Purity (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.