Description

Rolapitant (1S,2S,3S)-Isomer CAS NO 1214741-27-1 is a high-purity stereoisomer of the neurokinin-1 (NK-1) receptor antagonist, Rolapitant. This specific isomer is a critical pharmaceutical intermediate and reference standard essential for the development and quality control of antiemetic medications. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the synthesis of active pharmaceutical ingredients (APIs) and the development of new therapeutic formulations. The compound's defined stereochemistry is vital for ensuring biological activity and meeting stringent regulatory requirements for drug substance characterization.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of the finished drug substance, Rolapitant.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control (QC) testing of APIs and finished dosage forms.
• Process Research & Development: Serves as a benchmark in route scouting and optimization for the commercial manufacturing process.
• Impurity Profiling: Employed to identify, quantify, and control stereoisomeric impurities in the final API.
• Regulatory Submissions: Provides essential characterization data for drug master files (DMFs), investigational new drug (IND) applications, and new drug applications (NDAs).
• Clinical Trial Material: Used in the preparation of materials for non-clinical and clinical studies to ensure consistency and safety.

Basic Information

Item	Detail
Product Name	Rolapitant (1S,2S,3S)-Isomer
CAS No.	1214741-27-1
Molecular Formula	C₂₉H₃₃F₂N₃O₃
Molecular Weight	509.59 g/mol
Synonyms	(1S,2S,3S)-Rolapitant; (1S,2S,3S)-5-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-4-(4-fluoro-2-methylphenyl)-N-methyl-2-(methylsulfonyl)-N-[(2R)-1-azabicyclo[2.2.2]oct-2-yl]benzamide; Rolapitant Stereoisomer; Varubi Isomer; SCH 619734 Isomer; NK-1 Receptor Antagonist Isomer
EINECS	Contact for details

Quality Control

Every batch of Rolapitant (1S,2S,3S)-Isomer is manufactured under strict quality management systems. Our products undergo rigorous analytical testing to ensure compliance with pharmaceutical-grade standards, including identity, purity, and stereochemical integrity. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing results from tests such as HPLC assay, chiral purity, residual solvents, and related substances. We support regulatory filings with full traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.