Description

Rolapitant (1R,2R,3R)-Isomer is a specific stereoisomer of the neurokinin-1 (NK-1) receptor antagonist Rolapitant, identified by the CAS registry number 1214741-26-0. This high-purity intermediate is critical for ensuring the efficacy and safety profile of the final active pharmaceutical ingredient (API) used in antiemetic medications. Pharmaceutical manufacturers and advanced research organizations require this isomer for the development and production of therapeutics designed to prevent chemotherapy-induced nausea and vomiting (CINV). Its precise stereochemistry is essential for achieving the desired pharmacological activity and meeting stringent regulatory requirements for drug substance manufacturing.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: A key chiral building block in the multi-step synthesis of the Rolapitant API.
• Pharmaceutical R&D: Used in process development, optimization, and scale-up studies for antiemetic drug formulations.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in HPLC and chiral analysis.
• Preclinical & Clinical Studies: Employed in the production of drug candidates for pharmacokinetic, pharmacodynamic, and toxicology evaluations.
• Process Chemistry: Utilized in developing and validating stereoselective synthetic routes for complex pharmaceutical molecules.
• Regulatory Filings: Provides the necessary characterized material for Drug Master File (DMF) submissions and regulatory compliance documentation.

Basic Information

Item	Detail
Product Name	Rolapitant (1R,2R,3R)-Isomer
CAS No.	1214741-26-0
Molecular Formula	C25H27F6N3O2
Molecular Weight	515.49 g/mol
Synonyms	(1R,2R,3R)-5-[(5-Fluoro-1H-indol-3-yl)methyl]-3-[(2R)-2-[(1R)-3,5-bis(trifluoromethyl)phenyl]-2-(4-fluorophenyl)ethanoyl]-1,2,3,4-tetrahydro-2-methyl-2H-1,4-benzodiazepine; (1R,2R,3R)-Rolapitant; Rolapitant Isomer; Rolapitant Intermediate; SCH 619734 Isomer; Varubi Intermediate
EINECS	Contact for details

Quality Control

Our Rolapitant (1R,2R,3R)-Isomer is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including chiral purity determination by HPLC, identity confirmation by IR and MS, and stringent control of related substances and residual solvents. A Certificate of Analysis (COA) is provided with each shipment, detailing compliance with agreed specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability, consistency, and reliability for critical manufacturing applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Chiral Purity (HPLC)	≥ 99.0%
Related Substances (HPLC)	Any individual impurity ≤ 0.5%; Total impurities ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.