Description

Rolapitant (1R,2R,3S)-Isomer is a specific stereoisomer of the potent and selective neurokinin-1 (NK1) receptor antagonist, Rolapitant. This high-purity intermediate is critical for the synthesis of the active pharmaceutical ingredient (API) used in antiemetic medications to prevent chemotherapy-induced nausea and vomiting (CINV). It is essential for pharmaceutical R&D laboratories and API manufacturers requiring a reliable, high-quality building block for complex chiral synthesis.

Application

• Pharmaceutical Intermediate: Key chiral building block in the synthesis of the Rolapitant API.
• Antiemetic Drug Development: Used in research and production of medications targeting the NK1 receptor for CINV prevention.
• Process Chemistry & Scale-Up: Serves as a critical starting material for process optimization and commercial-scale manufacturing.
• Reference Standard: Can be utilized as an analytical standard for method development and quality control of the final API.
• Chiral Synthesis Studies: Valuable compound for research in stereoselective synthesis and pharmacology.

Basic Information

Product Name	Rolapitant (1R,2R,3S)-Isomer
CAS No.	1214741-25-9
Molecular Formula	C31H37F2NO4
Molecular Weight	525.63 g/mol
Synonyms	(1R,2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholine; (1R,2R,3S)-Rolapitant; Rolapitant Isomer; SCH 619734 Isomer; Rolapitant Chiral Intermediate; NK1 Receptor Antagonist Intermediate; Varubi Intermediate
EINECS	Contact for details

Quality Control

Our Rolapitant (1R,2R,3S)-Isomer is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity and chemical identity verification, to ensure it meets the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) with detailed HPLC, NMR, and MS data are provided to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.5%
Chiral Purity (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.