Description

Mal-Peg-Nh2 CAS NO 1207751-12-9 is a heterobifunctional polyethylene glycol (PEG) derivative featuring a maleimide group at one terminus and a primary amine group at the other. This bifunctionality is critical for creating stable, site-specific conjugates, enabling the precise linkage of biomolecules such as peptides, proteins, and antibodies. It is an essential reagent for researchers and manufacturers in the fields of bioconjugation, pharmaceutical development, and advanced material science, facilitating the creation of next-generation therapeutics and diagnostic tools.

Application

• Bioconjugation and Linker Chemistry: Site-specific conjugation of thiol-containing biomolecules (e.g., antibodies, cysteine-tagged proteins) via the maleimide group, while the amine group allows for further modification or attachment to other functional groups, surfaces, or molecules.
• ADC (Antibody-Drug Conjugate) Development: Serves as a versatile PEG-based linker/spacer to connect cytotoxic payloads to monoclonal antibodies, improving solubility, stability, and pharmacokinetic profiles of the resulting ADC.
• PEGylation of Therapeutics: Used to PEGylate peptides, proteins, and small molecule drugs to enhance their circulatory half-life, reduce immunogenicity, and improve solubility.
• Surface Functionalization: Modification of nanoparticles, quantum dots, and diagnostic assay surfaces to introduce reactive amine groups for subsequent biomolecule immobilization.
• Cross-linking Agent: Acts as a heterobifunctional cross-linker for coupling different molecules or materials, useful in hydrogel formation and polymer chemistry.
• Diagnostic Reagent Synthesis: Key intermediate in the synthesis of fluorescent probes, enzyme conjugates, and other reagents used in immunoassays and biosensors.

Basic Information

Product Name	Mal-Peg-Nh2
CAS No.	1207751-12-9
Molecular Formula	Contact for details
Molecular Weight	Variable (based on PEG chain length, e.g., 2k, 5k, 10k Da)
Synonyms	Maleimide-PEG-Amine; MAL-PEG-NH2; Amine-PEG-Maleimide; mPEG-MAL-NH2; NH2-PEG-MAL; α-Maleimide-ω-amine Polyethylene Glycol; Heterobifunctional PEG Maleimide Amine; 3-Maleimidopropionic acid-PEG-amine; PEG-based Maleimide Amine Crosslinker
EINECS	Contact for details

Quality Control

Our Mal-Peg-Nh2 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity, consistent molecular weight, and functional group integrity, meeting the stringent requirements for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity (by NMR, HPLC), functional group substitution ratio, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). For long-term storage, keep under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and hydrolysis of the maleimide group. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or viscous liquid
PEG Molecular Weight (Nominal)	2,000 Da / 3,400 Da / 5,000 Da / 10,000 Da / 20,000 Da (or as requested)
Purity (HPLC)	≥ 95%
Maleimide Substitution	≥ 90%
Amine Substitution	≥ 90%
Water Content (KF)	≤ 1.0%
Solvents (Residual)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.