Description

(4S,4As,5Ar,12As)-9-Amino-4-(Dimethylamino)-7-Fluoro-1,4,4A,5,5A,6,11,12A-Octahydro-3,10,12,12A-Tetrahydroxy-1,11-Dioxo-2-Naphthacenecarboxamide is a high-purity, complex tetracycline derivative of significant interest in advanced pharmaceutical research and development. Its intricate stereochemistry and functional groups make it a critical intermediate or reference standard for synthesizing novel antibiotics and investigating new mechanisms of action against resistant bacterial strains. This compound is essential for pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on antimicrobial discovery and medicinal chemistry.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of next-generation tetracycline-class antibiotics.
• Reference Standard: Used for analytical method development, validation, and quality control (QC) in API manufacturing.
• Medicinal Chemistry Research: A vital compound for structure-activity relationship (SAR) studies to optimize antibacterial potency and pharmacokinetic profiles.
• Biochemical Assay Development: Employed in high-throughput screening (HTS) campaigns to identify novel bacterial protein inhibitors.
• Academic Research: Used in university and institutional labs to study bacterial resistance mechanisms and antibiotic modes of action.
• Process Chemistry: Acts as a precursor in scaling up synthetic routes for potential new drug candidates under GMP conditions.

Basic Information

Item	Detail
Product Name	(4S,4As,5Ar,12As)-9-Amino-4-(Dimethylamino)-7-Fluoro-1,4,4A,5,5A,6,11,12A-Octahydro-3,10,12,12A-Tetrahydroxy-1,11-Dioxo-2-Naphthacenecarboxamide
CAS No.	1207283-60-0
Molecular Formula	C₂₂H₂₄FN₃O₈
Molecular Weight	477.44 g/mol
Synonyms	9-Amino-4-(dimethylamino)-7-fluoro-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide; 7-Fluoro-9-amino Minocycline derivative; Fluorinated Tetracycline Intermediate; (4S,4aR,5aR,12aR)-9-Amino-4-(dimethylamino)-7-fluoro-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-2-naphthacenecarboxamide
EINECS	Contact for details

Quality Control

Our (4S,4As,5Ar,12As)-9-Amino-4-(Dimethylamino)-7-Fluoro-1,4,4A,5,5A,6,11,12A-Octahydro-3,10,12,12A-Tetrahydroxy-1,11-Dioxo-2-Naphthacenecarboxamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for stereochemical integrity, and comprehensive identification tests. We provide full traceability and detailed Certificates of Analysis (COA) to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its sensitivity, the container should be kept under an inert atmosphere (e.g., nitrogen) to prevent oxidation and moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Chiral Purity	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.